Cancer is a profoundly dynamic, heterogeneous and aggressive systemic ailment, with a
coordinated evolution of various types of tumor niches. Hypoxia plays an indispensable role …

Hypoxia exerts a profound impact on diverse aspects of cancer biology. Increasing evidence
has revealed novel functions of hypoxia in cancer cell epigenomics, epitranscriptomics …

Simple Summary Hormones and growth factors impact many processes in the cell.
Moreover, these molecules influence tumor growth, as does a lack of oxygen (hypoxia) that …

Hypoxia, a common feature of solid tumors, greatly hinders the efficacy of conventional
cancer treatments such as chemo-, radio-, and immunotherapy. The depletion of oxygen in …

[Frontiers in Bioscience 12, 4061-4078, May 1, 2007] 4061 Targeting the molecular effects of a
hypoxic tumor microenvironment L. Page 1 [Frontiers in Bioscience 12, 4061-4078, May 1, 2007] …

Hypoxia, a key aspect of the tumor microenvironment, plays a vital role in cell proliferation,
angiogenesis, metabolism, and the immune response within tumors. These factors …

In recent years, there has been great progress in the understanding of tumor biology and its
surrounding microenvironment. Solid tumors create regions with low oxygen levels …

Tumors serve as a prototype system to study the role of the hypoxic microenvironment and
gain insight in the regulation oxygen homeostasis. A series of biochemical and cell …

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …

Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …