Background Cancer patients are likely to undergo osteoporosis as consequence of hormone
manipulation and/or chemotherapy. Little is known about possible increased risk of fracture …

Metastatic lesions compromise the mechanical integrity of vertebrae, increasing the fracture
risk. Screw fixation is usually performed to guarantee spinal stability and prevent dramatic …

Vertebral fractures associated with the loss of structural integrity of neoplastic vertebrae are
common, and determined to the deterioration of the bone quality in the lesion area. The …

The assessment of risk of vertebral fracture in patients with lytic metastases is challenging,
due to the complexity in modelling the mechanical properties of this heterogeneous material …

Background Bone metastases may lead to spine instability and increase the risk of fracture.
Scoring systems are available to assess critical metastases, but they lack specificity, and …

Metastatic disease in the vertebral column compromises the structural stability of the spine
leading to increased risk of fracture. The complex patterns of osteolytic and osteoblastic …

Spinal metastatic disease occurs in up to one-third of all cancer patients. Advanced spread
can lead to vertebral burst fracture, which may result in neurologic compromise. Developing …

Metastatic involvement can disrupt the mechanical integrity of the spine, rendering vertebrae
susceptible to burst fracture and neurologic damage. Fracture risk assessment for patients …

Abstract Currently, the Spinal Instability Neoplastic Score system is used in clinics to
evaluate the risk of fracture in patients with spinal metastases. This method, however, does …

Introduction Pathologic vertebral fractures are a major clinical concern in the management of
cancer patients with metastatic spine disease. These fractures are a direct consequence of …