Background: Acetaminophen (APAP) is a common analgesic and antipyretic medicine that
can lead to acute liver injury at high doses. Crocin, a Crocus sativus' ingredient, has potent …

The objective of the present study is the treatment of oxidative damage caused by
acrylamide induced oxidative stress in rats with the administration of a strong antioxidant …

AbstractBackground: Thioacetamide is an experimentally used hepatotoxic substance. Its
hepatotoxicity is mainly due to increased cellular oxidative stress. Aim: To evaluate the …

Background: Among the many known adverse effects of methotrexate (MTX), hepatotoxicity
stands out as a major drawback that limits its therapeutic applicability. There is growing …

Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to
severe liver injury and potentially death. Oxidative stress is an important event in APAP …

Crocin, a bioactive molecule of saffron can be purely isolated from the saffron extract. It has
different pharmacological effects such as antioxidant and anticancer activities. Morphine is …

Acetaminophen is a commonly used analgesic drug that induces hepatotoxicity at high
doses and produces the acetaminophen metabolite N-acetyl-p-benzoquinone imine …

Objectives: Acetaminophen (APAP) toxicity is known to be common and potentially fatal.
This study aims to investigate the protective effects of hydroalcoholic extract, remaining from …

Crocin, the main constituent of saffron (Crocus sativus L.), is a natural carotenoid which is
known for its antioxidant activity. Liver as the organ that metabolizes many chemicals is one …

Background Paracetamol [N-acetyl-p-aminophenol (APAP)] is one of the frequently
prescribed antipyretics and analgesics; yet going over the recommended dose still poses a …