We conducted a comprehensive in vivo study evaluating the influence of type 2 diabetes
(T2D) on major cytochrome P450 (CYP 450) activities. These activities were assessed in 38 …

Aims Cytochrome P450 2E1 (CYP2E1) is thought to activate a number of protoxins, and has
been implicated in the development of liver disease. Increased hepatic expression of …

CYP3A4, the most abundant cytochrome P450 enzyme in the human liver and small
intestine, is responsible for the metabolism of about 50% of all marketed drugs. Numerous …

1, 25 (OH) 2D3 and 25 (OH) D3 have been associated with type 1 diabetes. Diverse
enzymes are involved in the synthesis of these metabolites: the 25-Vitamin-D-hydroxylase …

BACKGROUND AND PURPOSE Patients with diabetes mellitus require pharmacotherapy
with numerous medications. However, the effect of diabetes on drug biotransformation is not …

On the basis of the data currently available, the wild type cytochrome P450 2C19
(CYP2C19) gene appears to be absent in 2 to 6% of Caucasian populations and up to 20 …

Background Trimethoprim is a relatively selective inhibitor of the cytochrome P450 (CYP)
2C8 enzyme in vitro. Rifampin (INN, rifampicin) is a potent inducer of several CYP enzymes …

Cytochrome P450 2E1 (CYP2E1) is a phase I detoxification enzyme, which is induced by
chronic alcohol consumption. It is involved in the activation of numerous carcinogens and in …

The objective of this review is to evaluate the risks associated with the discovery and
development of cytochrome P450 (CYP) 3A substrates. CYP3A is the most abundant P450 …

CYP27B1 (25-hydroxyvitamin D3-1α-hydroxylase) catalyzes the metabolization of 25-
hydroxyvitamin D3 to 1, 25 (OH) 2D3 the most active natural Vitamin D metabolite. 1, 25 …