Currents of memory: recent progress, translational challenges, and ethical considerations in fornix deep brain stimulation trials for Alzheimer's disease

JNM Viaña, JC Vickers, MJ Cook, F Gilbert - Neurobiology of Aging, 2017 - Elsevier
The serendipitous discovery of triggered autobiographical memories and eventual memory
improvement in an obese patient who received fornix deep brain stimulation in 2008 paved …

Deep brain stimulation of fornix for memory improvement in Alzheimer's disease: A critical review

R Li, C Zhang, Y Rao, TF Yuan - Ageing research reviews, 2022 - Elsevier
Memory reflects the brain function in encoding, storage and retrieval of the data or
information, which is a fundamental ability for any live organism. The development of …

Deep brain stimulation targeting the fornix for mild Alzheimer dementia: design of the ADvance randomized controlled trial

KB Holroyd, L Fosdick, GS Smith… - Open Access Journal …, 2015 - Taylor & Francis
Background: There are currently few available treatments and no cure for Alzheimer disease
(AD), a growing public health burden. Animal models and an open-label human trial have …

Deep brain stimulation of fornix in Alzheimer's disease: From basic research to clinical practice

Z Liu, K Shu, Y Geng, C Cai… - European Journal of …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is one of the most common progressive neurodegenerative
diseases associated with the degradation of memory and cognitive ability. Current …

Deep brain stimulation targeting the fornix for mild Alzheimer dementia (the ADvance trial): a two year follow-up including results of delayed activation

JMS Leoutsakos, H Yan, WS Anderson… - Journal of …, 2018 - content.iospress.com
Background: Given recent challenges in developing new treatments for Alzheimer dementia
(AD), it is vital to explore alternate treatment targets, such as neuromodulation for circuit …

Symptomatic treatment of memory decline in Alzheimer's disease by deep brain stimulation: a feasibility study

D Fontaine, A Deudon, JJ Lemaire… - Journal of …, 2013 - content.iospress.com
Recent studies have suggested that memory circuits can be modulated by deep brain
stimulation (DBS). This propriety might be used to slow down cognitive decline in patients …

Ethical considerations for deep brain stimulation trials in patients with early-onset Alzheimer's disease

JNM Viaña, M Bittlinger… - Journal of Alzheimer's …, 2017 - content.iospress.com
Several studies of deep brain stimulation (DBS) of the fornix or the nucleus basalis of
Meynert have been recently conducted in people with Alzheimer's disease, with several …

[HTML][HTML] Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease

AS Ríos, S Oxenford, C Neudorfer, K Butenko… - Nature …, 2022 - nature.com
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with
mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that …

[HTML][HTML] A phase II study of fornix deep brain stimulation in mild Alzheimer's disease

AM Lozano, L Fosdick, MM Chakravarty… - Journal of …, 2016 - content.iospress.com
Background: Deep brain stimulation (DBS) is used to modulate the activity of dysfunctional
brain circuits. The safety and efficacy of DBS in dementia is unknown. Objective: To assess …

Current status of deep brain stimulation for Alzheimer's disease: from chance observation to clinical trials

DJ Lee, AM Lozano - Cold Spring Harbor symposia on …, 2018 - symposium.cshlp.org
Alzheimer's disease (AD) is a neurodegenerative disorder that results in significant memory
impairment and cognitive decline. Current medical treatment is aimed at treating AD …