Abstract Background Prostate cancer (PCa) models in mice and rats are limited by their size
and lack of a clearly delineated or easily accessible prostate gland. The canine PCa model …

BACKGROUND Rodent models are often suboptimal for translational research on human
prostate cancer (PCa). To better fill the gap with human, we refined the previously described …

Background There are limited preclinical orthotopic prostate cancer models due to the
technical complexity of surgical engraftment and tracking the tumor growth in the mouse …

Simple Summary This review explores in vivo models of prostate cancer currently published
in the literature, with the focus on the prostate cancer mouse models that have recently been …

The high prevalence of prostate cancer (PCa) in elderly men and technical advances in
early detection of localized PCa have led to continued efforts to develop new therapeutic …

Several preclinical murine models of prostate cancer (PCa) are currently used to investigate
PCa diagnosis and treatment [1]. However, no model replicates the setting of radical …

Abstract Background Orthotopic LNCaP xenograft mouse models closely mimic the
progression of androgen-dependent prostate cancer in humans; however, orthotopic …

We previously established 3 cell lines (PLS10, PLS20 and PLS30) from a chemically-
induced prostate carcinoma in F344 rats, and demonstrated high potential for metastasis in …

Prostate cancer is one of the most common cancers in men in the United States.
Comprehensive understanding of the biology contributing to prostate cancer will have …

Prostate cancer continues to be a major cause of morbidity and mortality in men around the
world. The field of prostate cancer research continues to be hindered by the lack of relevant …