The next generation virus‐like particle platform for the treatment of peanut allergy
Background Allergy to peanut is one of the leading causes of anaphylactic reactions among
food allergic patients. Immunization against peanut allergy with a safe and protective …
food allergic patients. Immunization against peanut allergy with a safe and protective …
Vaccine against peanut allergy based on engineered virus-like particles displaying single major peanut allergens
Background Peanut allergy is a severe and increasingly frequent disease with high medical,
psychosocial, and economic burden for affected patients and wider society. A causal, safe …
psychosocial, and economic burden for affected patients and wider society. A causal, safe …
Influence of antigen density and TLR ligands on preclinical efficacy of a VLP‐based vaccine against peanut allergy
PS Krenger, R Josi, J Sobczak, TLC Velazquez… - Allergy, 2024 - Wiley Online Library
Background Virus‐like particle (VLP) Peanut is a novel immunotherapeutic vaccine
candidate for the treatment of peanut allergy. The active pharmaceutical ingredient …
candidate for the treatment of peanut allergy. The active pharmaceutical ingredient …
[HTML][HTML] Masked delivery of allergen in nanoparticles safely attenuates anaphylactic response in murine models of peanut allergy
KR Hughes, MN Saunders, JJ Landers… - Frontiers in …, 2022 - frontiersin.org
Food allergy is a growing health concern worldwide. Current allergen-specific
immunotherapy (AIT) approaches require frequent dosing over extended periods of time and …
immunotherapy (AIT) approaches require frequent dosing over extended periods of time and …
Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy
OE Pagovich, B Wang, MJ Chiuchiolo… - Journal of Allergy and …, 2016 - Elsevier
Background Peanuts are the most common food to provoke fatal or near-fatal anaphylactic
reactions. Treatment with an anti-hIgE mAb is efficacious but requires frequent parenteral …
reactions. Treatment with an anti-hIgE mAb is efficacious but requires frequent parenteral …
Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy
Background Treatments to reverse peanut allergy remain elusive. Current clinical
approaches using peanut oral/sublingual immunotherapy are promising, but concerns about …
approaches using peanut oral/sublingual immunotherapy are promising, but concerns about …
A phase 1 study of heat/phenol‐killed, E. coli‐encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP‐123) for the treatment of …
Background Immunotherapy for peanut allergy may be limited by the risk of adverse
reactions. Objective To investigate the safety and immunologic effects of a vaccine …
reactions. Objective To investigate the safety and immunologic effects of a vaccine …
Engineering, characterization and in vitro efficacy of the major peanut allergens for use in immunotherapy
GA Bannon, G Cockrell, C Connaughton… - International archives of …, 2001 - karger.com
Background: Numerous strategies have been proposed for the treatment of peanut allergies,
but despite the steady advancement in our understanding of atopic immune responses and …
but despite the steady advancement in our understanding of atopic immune responses and …
[HTML][HTML] A single monoclonal antibody against the peanut allergen Ara h 2 protects against systemic and local peanut allergy
F Storni, G Cabral-Miranda, E Roesti, L Zha… - International archives of …, 2020 - karger.com
Background: Peanut allergy is the most prevalent and dangerous food allergy. Peanuts
consist of a large number of different allergens and peanut-allergic patients are frequently …
consist of a large number of different allergens and peanut-allergic patients are frequently …
Developing therapies for peanut allergy
M Bublin, H Breiteneder - International archives of allergy and …, 2015 - karger.com
Peanut allergy is an IgE-mediated, persisting immune disorder that is of major concern
worldwide. Currently, no routine immunotherapy is available to treat this often severe and …
worldwide. Currently, no routine immunotherapy is available to treat this often severe and …