The next generation virus‐like particle platform for the treatment of peanut allergy

JM Sobczak, PS Krenger, F Storni, MO Mohsen… - Allergy, 2023 - Wiley Online Library
Background Allergy to peanut is one of the leading causes of anaphylactic reactions among
food allergic patients. Immunization against peanut allergy with a safe and protective …

Vaccine against peanut allergy based on engineered virus-like particles displaying single major peanut allergens

F Storni, A Zeltins, I Balke, MD Heath… - Journal of Allergy and …, 2020 - Elsevier
Background Peanut allergy is a severe and increasingly frequent disease with high medical,
psychosocial, and economic burden for affected patients and wider society. A causal, safe …

Influence of antigen density and TLR ligands on preclinical efficacy of a VLP‐based vaccine against peanut allergy

PS Krenger, R Josi, J Sobczak, TLC Velazquez… - Allergy, 2024 - Wiley Online Library
Background Virus‐like particle (VLP) Peanut is a novel immunotherapeutic vaccine
candidate for the treatment of peanut allergy. The active pharmaceutical ingredient …

[HTML][HTML] Masked delivery of allergen in nanoparticles safely attenuates anaphylactic response in murine models of peanut allergy

KR Hughes, MN Saunders, JJ Landers… - Frontiers in …, 2022 - frontiersin.org
Food allergy is a growing health concern worldwide. Current allergen-specific
immunotherapy (AIT) approaches require frequent dosing over extended periods of time and …

Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy

OE Pagovich, B Wang, MJ Chiuchiolo… - Journal of Allergy and …, 2016 - Elsevier
Background Peanuts are the most common food to provoke fatal or near-fatal anaphylactic
reactions. Treatment with an anti-hIgE mAb is efficacious but requires frequent parenteral …

Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy

KD Srivastava, A Siefert, TM Fahmy, MJ Caplan… - Journal of Allergy and …, 2016 - Elsevier
Background Treatments to reverse peanut allergy remain elusive. Current clinical
approaches using peanut oral/sublingual immunotherapy are promising, but concerns about …

A phase 1 study of heat/phenol‐killed, E. coli‐encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP‐123) for the treatment of …

RA Wood, SH Sicherer, AW Burks, A Grishin… - Allergy, 2013 - Wiley Online Library
Background Immunotherapy for peanut allergy may be limited by the risk of adverse
reactions. Objective To investigate the safety and immunologic effects of a vaccine …

Engineering, characterization and in vitro efficacy of the major peanut allergens for use in immunotherapy

GA Bannon, G Cockrell, C Connaughton… - International archives of …, 2001 - karger.com
Background: Numerous strategies have been proposed for the treatment of peanut allergies,
but despite the steady advancement in our understanding of atopic immune responses and …

[HTML][HTML] A single monoclonal antibody against the peanut allergen Ara h 2 protects against systemic and local peanut allergy

F Storni, G Cabral-Miranda, E Roesti, L Zha… - International archives of …, 2020 - karger.com
Background: Peanut allergy is the most prevalent and dangerous food allergy. Peanuts
consist of a large number of different allergens and peanut-allergic patients are frequently …

Developing therapies for peanut allergy

M Bublin, H Breiteneder - International archives of allergy and …, 2015 - karger.com
Peanut allergy is an IgE-mediated, persisting immune disorder that is of major concern
worldwide. Currently, no routine immunotherapy is available to treat this often severe and …