Novel approaches to reactivate pertussis immunity

G Blanchard-Rohner - Expert Review of Vaccines, 2022 - Taylor & Francis
Introduction Whole cell and acellular pertussis vaccines have been very effective in
decreasing the deaths of neonates and infants from Bordetella pertussis. Despite high …

Pertussis vaccines: the first hundred years

N Guiso, BD Meade, CHW von König - Vaccine, 2020 - Elsevier
Vaccines against pertussis have been used for more than a hundred years. This review
describes the development of whole-cell (wP) and acellular pertussis (aP) vaccines, which …

Whole-cell and acellular pertussis vaccine: reflections on efficacy

M Alghounaim, Z Alsaffar, A Alfraij… - Medical Principles and …, 2022 - karger.com
Pertussis is a common respiratory infection caused by the bacterium Bordetella pertussis.
Although most cases occur in developing countries, it is considered endemic globally. The …

Roads to the development of improved pertussis vaccines paved by immunology

J Brummelman, MM Wilk, WGH Han… - Pathogens and …, 2015 - academic.oup.com
Current acellular pertussis vaccines have various shortcomings, which may contribute to
their suboptimal efficacy and waning immunity in vaccinated populations. This calls for the …

[HTML][HTML] Pertussis prevention: reasons for resurgence, and differences in the current acellular pertussis vaccines

S Esposito, P Stefanelli, NK Fry, G Fedele… - Frontiers in …, 2019 - frontiersin.org
Pertussis is an acute respiratory disease caused by Bordetella pertussis. Due to its
frequency and severity, prevention of pertussis has been considered an important public …

[HTML][HTML] The path to new pediatric vaccines against pertussis

C Locht - Vaccines, 2021 - mdpi.com
Whooping cough, or pertussis, mostly caused by Bordetella pertussis, is a respiratory
disease that affects all age groups, but severe and fatal pertussis occurs almost exclusively …

[HTML][HTML] Pertussis: acellular, whole-cell, new vaccines, what to choose?

C Locht - Expert review of vaccines, 2016 - Taylor & Francis
Pertussis or whooping cough, caused by Bordetella pertussis, is a severe respiratory
disease that can be fatal in young infants. Two types of vaccines are available and widely …

[HTML][HTML] Acellular pertussis vaccine components: today and tomorrow

KK Dewan, B Linz, SE DeRocco, ET Harvill - Vaccines, 2020 - mdpi.com
Pertussis is a highly communicable acute respiratory infection caused by Bordetella
pertussis. Immunity is not lifelong after natural infection or vaccination. Pertussis outbreaks …

Pertussis vaccine trials in the 1990s

LC Lambert - The Journal of infectious diseases, 2014 - academic.oup.com
The significant burden of disease due to pertussis, which predominantly affects newborns
during their first few months of life, was substantially decreased following the introduction of …

Pertussis vaccines: state-of-the-art and future trends

BE Tefon - Current Topics in Medicinal Chemistry, 2013 - ingentaconnect.com
Bordetella pertussis is the causative agent of whooping cough (pertussis) which is a
worldwide vaccine preventable acute respiratory illness that predominantly involves infants …