SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart

C Li, J Zhang, M Xue, X Li, F Han, X Liu, L Xu… - Cardiovascular …, 2019 - Springer
Background Hyperglycaemia associated with myocardial oxidative stress and fibrosis is the
main cause of diabetic cardiomyopathy. Empagliflozin, a sodium-glucose cotransporter 2 …

Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice

M Xue, T Li, Y Wang, Y Chang, Y Cheng, Y Lu… - Clinical …, 2019 - portlandpress.com
Cardiovascular complications contribute to the major mortality and morbidity in type 2
diabetes. Diabetic cardiomyopathy (DCM) is increasingly recognized as an important cause …

[HTML][HTML] The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats

S Steven, M Oelze, A Hanf, S Kröller-Schön, F Kashani… - Redox biology, 2017 - Elsevier
Hyperglycemia associated with inflammation and oxidative stress is a major cause of
vascular dysfunction and cardiovascular disease in diabetes. Recent data reports that a …

Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome

H Kusaka, N Koibuchi, Y Hasegawa, H Ogawa… - Cardiovascular …, 2016 - Springer
Background The potential benefit of SGLT2 inhibitors in metabolic syndrome is with
prediabetic stage unclear. This work was undertaken to investigate the non-glycemic effect …

Empagliflozin and liraglutide differentially modulate cardiac metabolism in diabetic cardiomyopathy in rats

NN Trang, CC Chung, TW Lee, WL Cheng… - International journal of …, 2021 - mdpi.com
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2
inhibitors (SGLT2is) are antihyperglycemic agents with cardioprotective properties against …

Empagliflozin ameliorates diabetic cardiomyopathy via attenuating oxidative stress and improving mitochondrial function

J Wang, X Huang, H Liu, Y Chen, P Li… - Oxidative medicine …, 2022 - Wiley Online Library
Diabetic cardiomyopathy (DCM) is considered to be a critical contributor to the development
of heart failure. Empagliflozin (EMPA), a sodium‐glucose cotransporter 2 inhibitor, has been …

Empagliflozin prevents from early cardiac injury post myocardial infarction in non-diabetic mice

Y Liu, M Wu, J Xu, B Xu, L Kang - European Journal of Pharmaceutical …, 2021 - Elsevier
Objectives Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been confirmed to
reduce the rate of rehospitalization for heart failure and cardiovascular death in diabetic …

The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin

V Quagliariello, M De Laurentiis, D Rea… - Cardiovascular …, 2021 - Springer
Background Empagliflozin (EMPA), a selective inhibitor of the sodium glucose co-transporter
2, reduced the risk of hospitalization for heart failure and cardiovascular death in type 2 …

The sodium-glucose co-transporter 2 inhibitor, empagliflozin, protects against diabetic cardiomyopathy by inhibition of the endoplasmic reticulum stress pathway

Y Zhou, W Wu - Cellular Physiology and Biochemistry, 2017 - karger.com
Abstract Background/Aims: This study aimed to determine whether or not the sodium-
glucose co-transporter 2 inhibitor, empagliflozin (EMPA), can protect against diabetic …

The sodium–glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats

HC Lee, YL Shiou, SJ Jhuo, CY Chang, PL Liu… - Cardiovascular …, 2019 - Springer
Background Sodium glucose co-transporter 2 inhibitor (SGLT2i), a new class of anti-diabetic
drugs acting on inhibiting glucose resorption by kidneys, is shown beneficial in reduction of …