Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits
It remains unknown to what extent gene-gene interactions contribute to complex traits. Here,
we introduce a new approach using predicted gene expression to perform exhaustive …
we introduce a new approach using predicted gene expression to perform exhaustive …
Probabilistic integration of transcriptome-wide association studies and colocalization analysis identifies key molecular pathways of complex traits
Integrative genetic association methods have shown great promise in post-GWAS (genome-
wide association study) analyses, in which one of the most challenging tasks is identifying …
wide association study) analyses, in which one of the most challenging tasks is identifying …
Identification of putative effector genes across the GWAS Catalog using molecular quantitative trait loci from 68 tissues and cell types
C Guo, KB Sieber, J Esparza-Gordillo, MR Hurle… - BioRxiv, 2019 - biorxiv.org
Identifying the effector genes from genome-wide association studies (GWAS) is a crucial
step towards understanding the biological mechanisms underlying complex traits and …
step towards understanding the biological mechanisms underlying complex traits and …
Integrative genomics: quantifying significance of phenotype-genotype relationships from multiple sources of high-throughput data
Given recent advances in the generation of high-throughput data such as whole-genome
genetic variation and transcriptome expression, it is critical to come up with novel methods to …
genetic variation and transcriptome expression, it is critical to come up with novel methods to …
Identifying latent genetic interactions in genome-wide association studies using multiple traits
The" missing" heritability of complex traits may be partly explained by genetic variants
interacting with other genes or environments that are difficult to specify, observe, and detect …
interacting with other genes or environments that are difficult to specify, observe, and detect …
CoMM-S2: a collaborative mixed model using summary statistics in transcriptome-wide association studies
Motivation Although genome-wide association studies (GWAS) have deepened our
understanding of the genetic architecture of complex traits, the mechanistic links that …
understanding of the genetic architecture of complex traits, the mechanistic links that …
Sharing of genes and pathways across complex phenotypes: a multilevel genome-wide analysis
Evidence from genome-wide association studies (GWAS) suggest that pleiotropic effects on
human complex phenotypes are very common. Recently, an atlas of genetic correlations …
human complex phenotypes are very common. Recently, an atlas of genetic correlations …
Integration of biological networks and pathways with genetic association studies
YV Sun - Human genetics, 2012 - Springer
Millions of genetic variants have been assessed for their effects on the trait of interest in
genome-wide association studies (GWAS). The complex traits are affected by a set of inter …
genome-wide association studies (GWAS). The complex traits are affected by a set of inter …
A network-based approach to prioritize results from genome-wide association studies
Genome-wide association studies (GWAS) are a valuable approach to understanding the
genetic basis of complex traits. One of the challenges of GWAS is the translation of genetic …
genetic basis of complex traits. One of the challenges of GWAS is the translation of genetic …
[HTML][HTML] The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological …
MD Ritchie, K Van Steen - Annals of translational medicine, 2018 - ncbi.nlm.nih.gov
One of the primary goals in this era of precision medicine is to understand the biology of
human diseases and their treatment, such that each individual patient receives the best …
human diseases and their treatment, such that each individual patient receives the best …