A DNA-triplex stabilizing purine (8-aminoguanine) is designed based on molecular
modeling and synthesized. The substitution of guanine by 8-aminoguanine largely stabilizes …

Classical models for DNA triple helix formation assume the stabilization of these structures
through the formation of Hoogsteen hydrogen bonds. This assumes that G-rich duplex DNA …

In this work we selected double-stranded DNA sequences capable of forming stable
triplexes at 20 or 50° C with corresponding 13mer purine oligo-nucleotides. This selection …

Incorporation of the modified base 5-(1-propynl)-2 '-deoxyuridine (propynylU) in the third
strand of a triplex leads to enhanced triplex stabilization. To investigate effects of the …

Revised Manuscript ReceivedSeptember 29, 1995® abstract: A 1.5 ns long molecular
dynamics simulation was conducted to compare the structure and stability of a model DNA …

Revised Manuscript Received April 18, 1991 abstract: We have investigated the structure
and physical chemistry of the d (C3T4C3)-2 [d (G3A4G3)] triple helix by polyacrylamide gel …

Purine• purine• pyrimidine (Pu• Pu• Py) DNA triplexes are formed by binding a purine-rich
oligonucleotide to the purine strand of a DNA duplex. The third strand assumes an …

Understanding the stability of the Purine• Purine• Pyrimidine (Pu• Pu• Py) triplex has been a
challenge for a number of years. It is generally accepted that the stabilization of this triplex …

The structure of parallel-stranded duplexes of DNA-containing a mixture of guanines (G) and
adenines (A) is studied by means of molecular dynamics (MD) simulation, as well as NMR …

Revised Manuscript Received July 16, 1991 abstract: The specificity of a homopyrimidine
oligonucleotide binding to a homopurine-homopyrimidine sequence on double-stranded …