Introduction: Asthma is a respiratory disorder typically characterized by T-helper type 2 (Th2)
inflammation that is mediated by cytokines, including IL-4, IL-5, and IL-13 …

Asthma is a major chronic disease ranging from mild to severe refractory disease and is
classified into various clinical phenotypes. Severe asthma is difficult to treat and frequently …

Asthma remains a global health problem and, therefore, more effective pharmacotherapy is
needed. This is particularly true for chronic and severe asthma. In these clinical phenotypes …

Steroid resistant severe asthma with predominant bronchial neutrophilic inflammation could
benefit from IL-17 targeted therapies. In this view, the definition of clinical phenotypes and …

Highlights•Th17 cells and cytokines are associated with the more severe phenotypes of
asthma.•IL-17A and IL-17F are associated with increased neutrophils in the airway.•IL-17A …

Asthma is characterized by chronic airway inflammation with intense eosinophil and
lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness …

Steroid‐insensitive asthma is an infrequent but problematic airway disease that presents
with persistent symptoms, airflow limitation, or recurrent exacerbations even when treated …

While there now exist effective treatments for type 2 high, eosinophilic asthma, there are no
specific therapies for 40–50% of people with asthma with other phenotypes, which result …

Asthma has long been characterized as a disease of dysregulated T-helper type 2 immune
responses to environmental allergens. Clinical studies suggest that asthma is a …

BACKGROUND: The chronic airway disease asthma causes significant burden to patients
as well as the healthcare system with limited options for prevention or cure. Inadequate …