ABSTRACT RIG-I is an intracellular RNA virus sensor that mediates a signaling pathway that
triggers the alpha/beta interferon (IFN-α/β) immune defenses. However, the mechanism for …

RIG-I is essential for host defense against viral pathogens, as it triggers the release of type I
interferons upon encounter with viral RNA molecules. In this study, we show that RIG-I is …

Recognition of invading viruses by the host is elicited by cellular sensors which trigger
signaling cascades that lead to type I interferon (IFN) gene expression. Retinoic acid …

Retinoic acid-inducible gene I (RIG-I) is a key sensor for viral RNA in the cytosol, and it
initiates a signaling cascade that leads to the establishment of an interferon (IFN)-mediated …

RIG‐I is our first line of defense against RNA viruses, serving as a pattern recognition
receptor that identifies molecular features common among dsRNA and ssRNA viral …

RIG-I is a cytosolic sensor of viral RNA that plays crucial roles in the induction of type I
interferons. The C-terminal domain (CTD) of RIG-I is responsible for the recognition of viral …

Retinoic-acid inducible gene I (RIG-I) is a major pattern recognition receptor of the innate
immune system. RIG-I is a cytoplasmic RNA helicase that is able to bind virus-specific RNA …

RIG-I is an RNA helicase containing caspase activation and recruitment domains (CARDs).
RNA binding and signaling by RIG-I are implicated in pathogen recognition and triggering of …

The RIG-I–like receptors, retinoic acid inducible gene-1 (RIG-I), melanoma differentiation-
associated protein 5, and laboratory of genetics and physiology-2, are cytoplasmic sensors …

Various cells in the body are capable of sensing infectious viruses and initiating reactions
collectively known as antiviral innate responses. These responses include the production of …