NF-κB is essential for effective transcription of primate lentiviral genomes and also activates
antiviral host genes. Here, we show that the early protein Nef of most primate lentiviruses …

The transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-
κB) plays a complex role during the replication of primate lentiviruses. On the one hand, NF …

Primate lentiviruses have evolved sophisticated strategies to suppress the immune
response of their host species. For example, HIV-2 and most simian immunodeficiency …

The human immunodeficiency virus (HIV) Nef protein plays a critical role in AIDS
pathogenesis by enhancing replication and survival of the virus within infected cells and by …

The accessory Nef protein allows human immunodeficiency virus type 1 (HIV-1) to persist at
high levels and to cause AIDS in infected humans. The function of HIV-1 group M subtype B …

In the subset of primate lentiviruses that contain a vpu gene—HIV-1 and its simian
precursors—the Nef protein has lost the ability to down-modulate CD3, block T cell …

More than a decade ago it was established that intact nef genes are critical for efficient viral
persistence and greatly accelerate disease progression in SIVmac-infected rhesus …

Human immunodeficiency virus type 1 (HIV-1) negative factor (Nef) has been shown to
down-regulate the transcription factors NF-kappa B and AP-1 in vitro. To define the …

Nef of primate lentiviruses is critical for high levels of viremia and the progression to AIDS.
Nef associates with and activates a serine/threonine kinase (Nef-associated kinase [NAK]) …

Nef is a multifunctional accessory protein of primate lentiviruses. Recently, it has been
shown that the ability of Nef to downmodulate CD4, CD28, and class I major …