Precise mapping of DNA methylation patterns in CpG islands has become essential for
understanding diverse biological processes such as the regulation of imprinted genes, X …

DNA methylation patterns in CpG-rich regions of promoter, CpG islands, are concerned in
regulation of gene expression in mammalian cells. Excessive methylation of CpG …

CpG island methylation has been linked to tumor suppressor gene inactivation in neoplasia
and may serve as a useful marker to clone novel cancer-related genes. We have developed …

CpG islands frequently contain gene promoters or exons 1 and are usually unmethylated in
normal cells 1, 2, 3. Methylation of CpG islands is associated with delayed replication …

The methylation of CpG islands is associated with transcriptional repression and, in cancer,
leads to the abnormal silencing of tumor suppressor genes. Because aberrant …

Aberrant methylation of promoter region CpG islands is associated with transcriptional
inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG …

DNA methylation is a covalent modification of the nucleotide cytosine that is stably inherited
at the dinucleotide CpG by somatic cells, and 70% of CpG dinucleotides in the genome are …

CpG island hypermethylation is known to be associated with gene silencing in cancer. This
epigenetic event is generally accepted as a stochastic process in tumor cells resulting from …

Promoter region CpG island methylation is associated with tumor suppressor gene silencing
in neoplasia. GenBank sequence analyses revealed that a number of CpG islands are …

Cytosine-5 DNA methylation occurs in the context of CpG dinucleotides in vertebrates.
Aberrant methylation of CpG islands in human tumors has been shown to cause …