Determinants and functions of mitochondrial behavior

K Labbé, A Murley, J Nunnari - Annual review of cell and …, 2014 - annualreviews.org
Mitochondria are ancient organelles evolved from bacteria. Over the course of evolution, the
behavior of mitochondria inside eukaryotic cells has changed dramatically, and the …

Metabolic regulation of mitochondrial dynamics

P Mishra, DC Chan - Journal of Cell Biology, 2016 - rupress.org
Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they
act as powerhouses to generate adenosine triphosphate from oxidation of nutrients. At the …

Mitochondria as cellular and organismal signaling hubs

K Shen, CL Pender, R Bar-Ziv, H Zhang… - Annual review of cell …, 2022 - annualreviews.org
Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …

The cell biology of mitochondrial membrane dynamics

M Giacomello, A Pyakurel, C Glytsou… - Nature reviews Molecular …, 2020 - nature.com
Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

[HTML][HTML] Sending out an SOS: mitochondria as a signaling hub

I Bohovych, O Khalimonchuk - Frontiers in Cell and Developmental …, 2016 - frontiersin.org
Normal cellular physiology is critically dependent on numerous mitochondrial activities
including energy conversion, cofactor and precursor metabolite synthesis, and regulation of …

[PDF][PDF] Mitochondria: more than just a powerhouse

HM McBride, M Neuspiel, S Wasiak - Current biology, 2006 - cell.com
Pioneering biochemical studies have long forged the concept that the mitochondria are the
'energy powerhouse of the cell'. These studies, combined with the unique evolutionary origin …

Mitochondrial biogenesis and clearance: a balancing act

C Ploumi, I Daskalaki, N Tavernarakis - The FEBS journal, 2017 - Wiley Online Library
Mitochondria are semi‐autonomous organelles of prokaryotic origin that are postulated to
have been acquired by eukaryotic cells through an early endosymbiotic event. Except for …

[PDF][PDF] Mitophagy and quality control mechanisms in mitochondrial maintenance

S Pickles, P Vigié, RJ Youle - Current Biology, 2018 - cell.com
The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …

Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks

AJ Anderson, TD Jackson, DA Stroud… - Open …, 2019 - royalsocietypublishing.org
Mitochondria are iconic structures in biochemistry and cell biology, traditionally referred to
as the powerhouse of the cell due to a central role in energy production. However, modern …

Hallmarks of a new era in mitochondrial biochemistry

DJ Pagliarini, J Rutter - Genes & development, 2013 - genesdev.cshlp.org
Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s,
mitochondria have become ingrained in the collective psyche of scientists as the …