[HTML][HTML] Ceramide function in the brain: when a slight tilt is enough
C Mencarelli, P Martinez–Martinez - Cellular and Molecular Life Sciences, 2013 - Springer
Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …
Sphingolipids in neurodegeneration (with focus on ceramide and S1P)
G Wang, E Bieberich - Advances in biological regulation, 2018 - Elsevier
For many decades, research on sphingolipids associated with neurodegenerative disease
focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides) …
focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides) …
[HTML][HTML] Ceramide metabolism and Parkinson's disease—therapeutic targets
A Custodia, M Aramburu-Núñez, C Correa-Paz… - Biomolecules, 2021 - mdpi.com
Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to
being the precursor of complex sphingolipids, ceramides can act as second messengers …
being the precursor of complex sphingolipids, ceramides can act as second messengers …
The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases
O Ben-David, AH Futerman - Neuromolecular medicine, 2010 - Springer
Ceramide forms the backbone of all complex sphingolipids and has been the focus of
considerable attention in the past few years due to the discovery that ceramide plays vital …
considerable attention in the past few years due to the discovery that ceramide plays vital …
[HTML][HTML] The role of ceramide and sphingosine-1-phosphate in Alzheimer's disease and other neurodegenerative disorders
K Czubowicz, H Jęśko, P Wencel, WJ Lukiw… - Molecular …, 2019 - Springer
Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …
Ceramide and other sphingolipids in cellular responses
J Yang, Y Yu, S Sun, PJ Duerksen-Hughes - Cell biochemistry and …, 2004 - Springer
Formerly considered to serve only as structural components, sphingolipids are emerging as
an important group of signaling molecules involved in many cellular events, including cell …
an important group of signaling molecules involved in many cellular events, including cell …
Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease
K Yuyama, S Mitsutake, Y Igarashi - … Acta (BBA)-Molecular and Cell Biology …, 2014 - Elsevier
The public health burden of metabolic syndrome (MetS), a multiplex risk factor that arises
from insulin resistance accompanying abnormal adipose conditions, and Alzheimer's …
from insulin resistance accompanying abnormal adipose conditions, and Alzheimer's …
[HTML][HTML] Astrocytic ceramide as possible indicator of neuroinflammation
NM De Wit, S Den Hoedt, P Martinez-Martinez… - Journal of …, 2019 - Springer
Background Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's
disease dementia (PDD), and frontotemporal lobar dementia (FTLD) are characterized by …
disease dementia (PDD), and frontotemporal lobar dementia (FTLD) are characterized by …
Biophysics of ceramide signaling: interaction with proteins and phase transition of membranes
M Krönke - Chemistry and Physics of Lipids, 1999 - Elsevier
Ceramides have been implied in intracellular signal transduction systems regulating cellular
differentiation, activation, survival and apoptosis and thus appear capable of changing the …
differentiation, activation, survival and apoptosis and thus appear capable of changing the …
[HTML][HTML] Diverse roles of ceramide in the progression and pathogenesis of Alzheimer's disease
MR Chowdhury, HK Jin, J Bae - Biomedicines, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder, and is
associated with several pathophysiological features, including cellular dysfunction, failure of …
associated with several pathophysiological features, including cellular dysfunction, failure of …