Spontaneous preterm birth is a serious medical condition responsible for substantial
perinatal morbidity and mortality. Its phenotypic characteristics, preterm labor with intact …

Placental homeostasis of tryptophan is essential for fetal development and programming.
The two main metabolic pathways (serotonin and kynurenine) produce bioactive metabolites …

l-Tryptophan is an essential amino acid and a precursor of several physiologically active
metabolites. In the placenta, the serotonin and kynurenine metabolic pathways of tryptophan …

Introduction Spontaneous preterm birth (sPTB), which predominantly presents as
spontaneous preterm labor (sPTL) or prelabor premature rupture of membranes (PPROM) …

Maternal immune activation during pregnancy is a risk factor for offspring neuropsychiatric
disorders. Among the mechanistic pathways by which maternal inflammation can affect fetal …

Background Spontaneous preterm birth accounts for most preterm births and leads to
significant morbidity in the newborn and childhood period. This subtype of preterm birth …

Maternal inflammation during pregnancy affects placental function and is associated with
increased risk of neurodevelopmental disorders in the offspring. The molecular mechanisms …

Background Pre-term birth (PTB) remains the leading cause of infant mortality and morbidity.
Its etiology is multifactorial, with a strong genetic component. Genetic predisposition for the …

Background Preterm birth (PTB), defined as infant delivery before 37 weeks of completed
gestation, results from the interaction of both genetic and environmental components and …

Background: Despite decades of research, the pathogenesis of spontaneous preterm birth
(PTB) remains largely unknown. Limited currently available data on PTB pathogenesis are …