One of the hallmarks of cancer is the ability to activate invasion and metastasis. Cancer
morbidity and mortality are largely related to the spread of the primary, localized tumour to …

Tumours progress through a cascade of events that enable the formation of metastases.
Some of the components that are required for this fatal process are well established …

Tetraspanins are a superfamily of small transmembrane proteins that are expressed in
almost all eukaryotic cells. Through interacting with one another and with other membrane …

Tetraspanin CD82 suppresses the progression and metastasis of a wide range of solid
malignant tumors. However, its roles in tumorigenesis and hematopoietic malignancy …

Originally identified as a molecular organizer of interacting proteins into tetraspanin-
enriched microdomains, the tetraspanin CD151 has now been shown to be involved in …

Transmembrane protein tetraspanins either promote or suppress tumor invasion and
metastasis. Their effects on tumor progression depend on the multimolecular …

Normal physiology relies on the organization of transmembrane proteins by molecular
scaffolds, such as tetraspanins. Oncogenesis frequently involves changes in their …

Human tetraspanin proteins are a group of 33 highly hydrophobic membrane proteins that
can form complexes in cholesterol‐rich microdomains, distinct from lipid rafts, on the cell …

Tetraspanins, also called tetraspans or the transmembrane 4 superfamily (TM4SF), are cell-
surface proteins that span the membrane four times and are found on many different cell …

Zusammenfassung Tumoren des Magen-Darm-Traktes unter Einschluss von Malignomen
des Magens, des Kolorektum, der Leber und des Pankreas umfassen weltweit über 50 …