Cannabis has been used for hundreds of years, with its ability to dampen feelings of anxiety
often reported as a primary reason for use. Only recently has the specific role cannabinoids …

The term cannabinoids encompasses compounds produced by the plant Cannabis sativa,
such as Δ 9-tetrahydrocannabinol, and synthetic counterparts. Their actions occur mainly …

The last decade has witnessed remarkable progress in the understanding of the mammalian
cannabinoid system, from the cloning of the endogenous cannabinoid receptor to the …

Cannabinoid agonists induce complex and often contradictory effects on anxiety in humans
and experimental animals. The data from animal tests provide evidence of dose-dependent …

Extracts of Cannabis sativa have been used for their calming and sedative effects for
centuries. Recent developments in drug discovery have suggested that modulation of …

Anandamide and 2-arachidonoyl glycerol, referred to as endocannabinoids (eCBs), are the
endogenous agonists for the cannabinoid receptor type 1 (CB1). Several pieces of evidence …

Evidence for the involvement of the endocannabinoid system (ECS) in anxiety and fear has
been accumulated, providing leads for novel therapeutic approaches. In anxiety, a …

Observational studies in humans suggest that exposure to marijuana and other cannabis‐
derived drugs produces a wide range of subjective effects on mood tone and emotionality …

The endocannabinoid system plays an important role in the control of emotions, and its
dysregulation has been implicated in several psychiatric disorders. The most common self …

Cannabinoid receptors and their endogenous ligands are located throughout the limbic, or
“emotional,” brain, where they modulate synaptic neurotransmission. Converging preclinical …