An orbitofrontal cortex–anterior insular cortex circuit gates compulsive cocaine use
Y Chen, G Wang, W Zhang, Y Han, L Zhang, H Xu… - Science …, 2022 - science.org
Compulsive drug use, a cardinal symptom of drug addiction, is characterized by persistent
substance use despite adverse consequences. However, little is known about the neural …
substance use despite adverse consequences. However, little is known about the neural …
Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats
RA Fuchs, KA Evans, MP Parker… - Journal of …, 2004 - Soc Neuroscience
Orbitofrontal cortex (OFC) damage elicits impulsivity and perseveration, and impairments in
OFC function may underlie compulsive drug seeking in cocaine users. To test this …
OFC function may underlie compulsive drug seeking in cocaine users. To test this …
Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity
S Bariselli, NL Miyazaki, MC Creed… - Nature communications, 2020 - nature.com
Psychomotor stimulants increase dopamine levels in the striatum and promote locomotion;
however, their effects on striatal pathway function in vivo remain unclear. One model that …
however, their effects on striatal pathway function in vivo remain unclear. One model that …
Gene network dysregulation in dorsolateral prefrontal cortex neurons of humans with cocaine use disorder
EA Ribeiro, JR Scarpa, SP Garamszegi, A Kasarskis… - Scientific reports, 2017 - nature.com
Metabolic and functional alterations of neurons in the dorsolateral prefrontal cortex (dlPFC)
are thought to contribute to impulsivity, which is a hallmark of addictive behaviors that …
are thought to contribute to impulsivity, which is a hallmark of addictive behaviors that …
[引用][C] The effects of selective orbitofrontal cortex lesions on the acquisition and performance of cue‐controlled cocaine seeking in rats
DM Hutcheson, BJ Everitt - Annals of the New York Academy of …, 2003 - Wiley Online Library
Yann Pelloux, Jennifer E. Murray and Barry J. Everitt, Differential roles of the prefrontal
cortical subregions and basolateral amygdala in compulsive cocaine seeking and relapse …
cortical subregions and basolateral amygdala in compulsive cocaine seeking and relapse …
Involvement of the lateral orbitofrontal cortex in drug context‐induced reinstatement of cocaine‐seeking behavior in rats
HC Lasseter, DR Ramirez, X Xie… - European Journal of …, 2009 - Wiley Online Library
Orbitofrontal cortex (OFC) damage produces impaired decision‐making, impulsivity and
perseveration and potentially contributes to compulsive drug seeking in cocaine users. To …
perseveration and potentially contributes to compulsive drug seeking in cocaine users. To …
[HTML][HTML] The roles of rat medial prefrontal and orbitofrontal cortices in relapse to cocaine-seeking: A comparison across methods for identifying neurocircuits
JR Mesa, DW Wesson, M Schwendt… - Addiction neuroscience, 2022 - Elsevier
A large body of research supports the notion that regions of the rodent frontal cortex regulate
reinstatement of cocaine seeking after cessation of intravenous cocaine self-administration …
reinstatement of cocaine seeking after cessation of intravenous cocaine self-administration …
Bidirectional regulation over the development and expression of loss of control over cocaine intake by the anterior insula
Rationale Increasing evidence suggests that the anterior insular cortex (AIC) plays a major
role in cocaine addiction, being implicated in both impaired insight and associated decision …
role in cocaine addiction, being implicated in both impaired insight and associated decision …
Orbitofrontal cortex and cognitive‐motivational impairments in psychostimulant addiction: evidence from experiments in the non‐human primate
P Olausson, JD Jentsch, DD Krueger… - Annals of the New …, 2007 - Wiley Online Library
Addiction is characterized by compulsive drug use despite adverse consequences. The
precise psychobiological changes that underlie the progression from casual use to loss of …
precise psychobiological changes that underlie the progression from casual use to loss of …
Role of the GABAa and GABAb receptors of the central nucleus of the amygdala in compulsive cocaine-seeking behavior in male rats
WL Sun, MB Yuill - Psychopharmacology, 2020 - Springer
Rationale Compulsive cocaine use, defined as the continued use despite the dire
consequences, is a hallmark of cocaine addiction. Thus, understanding the brain …
consequences, is a hallmark of cocaine addiction. Thus, understanding the brain …