Compulsive drug use, a cardinal symptom of drug addiction, is characterized by persistent
substance use despite adverse consequences. However, little is known about the neural …

Orbitofrontal cortex (OFC) damage elicits impulsivity and perseveration, and impairments in
OFC function may underlie compulsive drug seeking in cocaine users. To test this …

Psychomotor stimulants increase dopamine levels in the striatum and promote locomotion;
however, their effects on striatal pathway function in vivo remain unclear. One model that …

Metabolic and functional alterations of neurons in the dorsolateral prefrontal cortex (dlPFC)
are thought to contribute to impulsivity, which is a hallmark of addictive behaviors that …

Yann Pelloux, Jennifer E. Murray and Barry J. Everitt, Differential roles of the prefrontal
cortical subregions and basolateral amygdala in compulsive cocaine seeking and relapse …

Orbitofrontal cortex (OFC) damage produces impaired decision‐making, impulsivity and
perseveration and potentially contributes to compulsive drug seeking in cocaine users. To …

A large body of research supports the notion that regions of the rodent frontal cortex regulate
reinstatement of cocaine seeking after cessation of intravenous cocaine self-administration …

Rationale Increasing evidence suggests that the anterior insular cortex (AIC) plays a major
role in cocaine addiction, being implicated in both impaired insight and associated decision …

Addiction is characterized by compulsive drug use despite adverse consequences. The
precise psychobiological changes that underlie the progression from casual use to loss of …

Rationale Compulsive cocaine use, defined as the continued use despite the dire
consequences, is a hallmark of cocaine addiction. Thus, understanding the brain …