The 'cancer stem cell'hypothesis has pointed to a specific target for new cancer therapies.
The hypothesis is based on the observation that only the 'cancer stem cell'among the other …

Over 90% of all human neoplasia is derived from epithelia. Significant progress has been
made in the identification of stem cells of many epithelia. In general, epithelial stem cells …

Stem cells and cancer are inextricably linked; the process of carcinogenesis initially affects
normal stem cells or their closely related progenitors and then, at some point, neoplastic …

Since the declaration of war on cancer some four decades ago, there has been an
exponential growth in our understanding of the genetic and cellular mechanisms that …

Definite evidence of the importance of cancer stem cells in the progression of cancer has
now come to light. Key markers of these cells have been identified in many solid tumours as …

Cancer stem cells and their potential roles in tumor heterogeneity are currently subjects of
intense investigation. Studies suggest that these cells may develop from any normal cell and …

54 SCIENTIFIC AMERICAN JULY 2006 are called cancer stem cells. But they are also quite
literally believed to have once been normal stem cells or their immature offspring that have …

The functional capabilities of normal stem cells and tumorigenic cancer cells are
conceptually similar in that both cell types are able to proliferate extensively. Indeed …

Understanding the process of carcinogenesis will involve both the accumulation of many
scientific facts derived from molecular, biochemical, cellular, physiological, whole animal …

Most human cancers derive from a single cell targeted by genetic and epigenetic alterations
that initiate malignant transformation. Progressively, these early cancer cells give rise to …