Abstract Knowledge of the elastic properties of DNA is required to understand the structural
dynamics of cellular processes such as replication and transcription. Measurements of force …

The basic features of DNA were elucidated during the half-century following the discovery of
the double helix. But it is only during the past decade that researchers have been able to …

DNA is often modelled as an isotropic rod,,,, but its chiral structure suggests the possible
importance of anisotropic mechanical properties, including coupling between twisting and …

We introduce magnetic torque tweezers, which enable direct single-molecule
measurements of torque. Our measurements of the effective torsional stiffness C of dsDNA …

The elastic properties of DNA are essential for its biological function. They control its
bending and twisting as well as the induction of structural modifications in the molecule …

From the first high-resolution structure of a repressor bound specifically to its DNA
recognition sequence1 it has been shown that the phage 434 repressor protein binds as a …

We have used triplet anisotropy decay techniques to study the flexibility of synthetic DNA
fragments with different base pair compositions. We have found major differences in the …

The force-displacement response of a single duplex DNA molecule was measured. The
force saturates at a plateau around 70 piconewtons, which ends when the DNA has been …

During the past decade, physical techniques such as optical tweezers and atomic force
microscopy were used to study the mechanical properties of DNA at the single-molecule …

DNA torsional elastic properties play a crucial role in DNA structure, topology, and the
regulation of motor protein progression. However, direct measurements of these parameters …