[HTML][HTML] Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection

CB Sturdevant, SB Joseph, G Schnell, RW Price… - PLoS …, 2015 - journals.plos.org
Compartmentalized HIV-1 replication within the central nervous system (CNS) likely
provides a foundation for neurocognitive impairment and a potentially important tissue …

Human immunodeficiency virus type 1 RNA detected in the central nervous system (CNS) after years of suppressive antiretroviral therapy can originate from a …

SB Joseph, LP Kincer, NM Bowman… - Clinical Infectious …, 2019 - academic.oup.com
Background Human immunodeficiency virus type 1 (HIV-1) populations are detected in
cerebrospinal fluid (CSF) of some people on suppressive antiretroviral therapy (ART) …

Compartmentalized human immunodeficiency virus type 1 present in cerebrospinal fluid is produced by short-lived cells

PR Harrington, DW Haas, K Ritola… - Journal of virology, 2005 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS)
during primary infection and persists in this compartment by unknown mechanisms over the …

[HTML][HTML] HIV-1 replication in the central nervous system occurs in two distinct cell types

G Schnell, S Joseph, S Spudich, RW Price… - PLoS …, 2011 - journals.plos.org
Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS)
can lead to the development of HIV-1-associated dementia (HAD). We examined the …

[HTML][HTML] Early antiretroviral therapy is associated with lower HIV DNA molecular diversity and lower inflammation in cerebrospinal fluid but does not prevent the …

MF Oliveira, A Chaillon, M Nakazawa, M Vargas… - PLoS …, 2017 - journals.plos.org
Even when antiretroviral therapy (ART) is started early after infection, HIV DNA might persist
in the central nervous system (CNS), possibly contributing to inflammation, brain damage …

Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy

S Gianella, SL Kosakovsky Pond, MF Oliveira… - Virus …, 2016 - academic.oup.com
To design effective eradication strategies, it may be necessary to target HIV reservoirs in
anatomic compartments other than blood. This study examined HIV RNA rebound following …

Compartmentalization, viral evolution, and viral latency of HIV in the CNS

MM Bednar, CB Sturdevant, LA Tompkins… - Current HIV/AIDS …, 2015 - Springer
Human immunodeficiency virus type 1 (HIV-1) infection occurs throughout the body and can
have dramatic physical effects, such as neurocognitive impairment in the central nervous …

Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection

G Schnell, RW Price, R Swanstrom… - Journal of virology, 2010 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) is a severe
neurological disease that affects a subset of HIV-1-infected individuals. Increased …

[HTML][HTML] T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy

G Lustig, S Cele, F Karim, A Derache, A Ngoepe… - PLoS …, 2021 - journals.plos.org
HIV cerebrospinal fluid (CSF) escape, where HIV is suppressed in blood but detectable in
CSF, occurs when HIV persists in the CNS despite antiretroviral therapy (ART). To determine …

[HTML][HTML] Compartmentalized human immunodeficiency virus type 1 originates from long-lived cells in some subjects with HIV-1–associated dementia

G Schnell, S Spudich, P Harrington, RW Price… - PLoS …, 2009 - journals.plos.org
Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS)
shortly after systemic infection and can result in the subsequent development of HIV-1 …