Spinal cord repair: advances in biology and technology

G Courtine, MV Sofroniew - Nature medicine, 2019 - nature.com
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …

Therapeutic interventions after spinal cord injury

S Thuret, LDF Moon, FH Gage - Nature Reviews Neuroscience, 2006 - nature.com
Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …

Emerging repair, regeneration, and translational research advances for spinal cord injury

BK Kwon, LH Sekhon, MG Fehlings - Spine, 2010 - journals.lww.com
Study Design. Literature review of basic scientific and clinical research in spinal cord injury
(SCI). Objective. To provide physicians with an overview of the neurobiologic challenges of …

Experimental strategies to promote spinal cord regeneration—an integrative perspective

JM Schwab, K Brechtel, CA Mueller, V Failli… - Progress in …, 2006 - Elsevier
Detailed pathophysiological findings of secondary damage phenomena after spinal cord
injury (SCI) as well as the identification of inhibitory and neurotrophic proteins have yielded …

The translational landscape in spinal cord injury: focus on neuroplasticity and regeneration

TH Hutson, S Di Giovanni - Nature Reviews Neurology, 2019 - nature.com
Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Spinal cord injury: plasticity, regeneration and the challenge of translational drug development

A Blesch, MH Tuszynski - Trends in neurosciences, 2009 - cell.com
Over the past three decades, multiple mechanisms limiting central nervous system
regeneration have been identified. Here, we address plasticity arising from spared systems …

Recent progress and challenges in the treatment of spinal cord injury

T Tian, S Zhang, M Yang - Protein & cell, 2023 - academic.oup.com
Spinal cord injury (SCI) disrupts the structural and functional connectivity between the higher
center and the spinal cord, resulting in severe motor, sensory, and autonomic dysfunction …

Regenerative therapies for spinal cord injury

N Ashammakhi, HJ Kim, A Ehsanipour… - … Engineering Part B …, 2019 - liebertpub.com
Spinal cord injury (SCI) is a serious problem that primarily affects younger and middle-aged
adults at its onset. To date, no effective regenerative treatment has been developed. Over …

Spinal cord injury and plasticity: opportunities and challenges

K Fouad, A Krajacic, W Tetzlaff - Brain research bulletin, 2011 - Elsevier
There is still no effective treatment to promote functional recovery following spinal cord
injury. However, promoting injury-induced adaptive changes (plasticity) within the central …