Spinal cord repair: advances in biology and technology
G Courtine, MV Sofroniew - Nature medicine, 2019 - nature.com
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …
Advances in clinical management have decreased morbidity and improved outcomes, but …
Therapeutic interventions after spinal cord injury
Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …
Emerging repair, regeneration, and translational research advances for spinal cord injury
Study Design. Literature review of basic scientific and clinical research in spinal cord injury
(SCI). Objective. To provide physicians with an overview of the neurobiologic challenges of …
(SCI). Objective. To provide physicians with an overview of the neurobiologic challenges of …
Experimental strategies to promote spinal cord regeneration—an integrative perspective
JM Schwab, K Brechtel, CA Mueller, V Failli… - Progress in …, 2006 - Elsevier
Detailed pathophysiological findings of secondary damage phenomena after spinal cord
injury (SCI) as well as the identification of inhibitory and neurotrophic proteins have yielded …
injury (SCI) as well as the identification of inhibitory and neurotrophic proteins have yielded …
The translational landscape in spinal cord injury: focus on neuroplasticity and regeneration
TH Hutson, S Di Giovanni - Nature Reviews Neurology, 2019 - nature.com
Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …
Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem
JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …
Spinal cord injury: plasticity, regeneration and the challenge of translational drug development
A Blesch, MH Tuszynski - Trends in neurosciences, 2009 - cell.com
Over the past three decades, multiple mechanisms limiting central nervous system
regeneration have been identified. Here, we address plasticity arising from spared systems …
regeneration have been identified. Here, we address plasticity arising from spared systems …
Recent progress and challenges in the treatment of spinal cord injury
T Tian, S Zhang, M Yang - Protein & cell, 2023 - academic.oup.com
Spinal cord injury (SCI) disrupts the structural and functional connectivity between the higher
center and the spinal cord, resulting in severe motor, sensory, and autonomic dysfunction …
center and the spinal cord, resulting in severe motor, sensory, and autonomic dysfunction …
Regenerative therapies for spinal cord injury
Spinal cord injury (SCI) is a serious problem that primarily affects younger and middle-aged
adults at its onset. To date, no effective regenerative treatment has been developed. Over …
adults at its onset. To date, no effective regenerative treatment has been developed. Over …
Spinal cord injury and plasticity: opportunities and challenges
K Fouad, A Krajacic, W Tetzlaff - Brain research bulletin, 2011 - Elsevier
There is still no effective treatment to promote functional recovery following spinal cord
injury. However, promoting injury-induced adaptive changes (plasticity) within the central …
injury. However, promoting injury-induced adaptive changes (plasticity) within the central …