[HTML][HTML] Exposure of Cryptococcus neoformans to Seven Commonly Used Agricultural Azole Fungicides Induces Resistance to Fluconazole as Well as Cross …

P Drakulovski, D Krasteva, V Bellet, S Randazzo… - Pathogens, 2023 - mdpi.com
Background: Cross-resistance to medical azoles by exposure to azole pesticides is well
documented for Aspergillus family fungi but is poorly evaluated for other environmental …

Could Fungicides Lead to Azole Drug Resistance in a Cross-Resistance Manner among Environmental Cryptococcus Strains?

JPF Takahashi, LM Feliciano, DCS Santos… - Current Fungal Infection …, 2020 - Springer
Abstract Purpose of Review Acquired resistance among fungal strains is a growing concern.
The reasons for the emergence of this phenomenon, with great clinical implications, are only …

Environmental triazole induces cross-resistance to clinical drugs and affects morphophysiology and virulence of Cryptococcus gattii and C. neoformans

RW Bastos, HCS Carneiro, LVN Oliveira… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Cryptococcus gattii and Cryptococcus neoformans are environmental fungi that cause
cryptococcosis, which is usually treated with amphotericin B and fluconazole. However …

From the environment to the host: how non-azole agrochemical exposure affects the antifungal susceptibility and virulence of Cryptococcus gattii

RW Bastos, GJC Freitas, HCS Carneiro… - Science of the Total …, 2019 - Elsevier
Agrochemicals such as the non-azoles, used to improve crop productivity, poses severe
undesirable effects on the environment and human health. In addition, they induce cross …

Cross‐resistance to fluconazole induced by exposure to the agricultural azole tetraconazole: an environmental resistance school?

MFG Rocha, LP Alencar, MAN Paiva, LM Melo… - Mycoses, 2016 - Wiley Online Library
This study aimed to investigate the influence of tetraconazole and malathion, both used in
agricultural activities, on resistance to fluconazole, itraconazole and voriconazole in …

Effects of environmental factors on sensitivity of Cryptococcus neoformans to fluconazole and amphotericin B

T Carlson, E Lupinacci, K Moseley… - FEMS Microbiology …, 2021 - academic.oup.com
Cryptococcus neoformans is a leading cause of fungal meningitis in immunocompromized
populations. Amphotericin B (AMB) and fluconazole (FLC) are common anticryptococcal …

Rates of antifungal resistance among Spanish clinical isolates of Cryptococcus neoformans var. neoformans

A Perkins, A Gomez-Lopez, E Mellado… - Journal of …, 2005 - academic.oup.com
Objectives: Activities in vitro of six antifungal agents were tested against a collection of 317
Cryptococcus neoformans var. neoformans clinical isolates. Methods: The procedure …

Collateral consequences of agricultural fungicides on pathogenic yeasts: A One Health perspective to tackle azole resistance

D Castelo‐Branco, SR Lockhart, YC Chen… - Mycoses, 2022 - Wiley Online Library
Candida and Cryptococcus affect millions of people yearly, being responsible for a wide
array of clinical presentations, including life‐threatening diseases. Interestingly, most human …

[HTML][HTML] African ST173 Cryptococcus deuterogattii strains are commonly less susceptible to fluconazole: an unclear mechanism of resistance

S Bertout, F Roger, P Drakulovski, AS Martin… - Journal of Global …, 2020 - Elsevier
Objectives Fluconazole (FCZ), either alone or in combination, is often administered for
treatment of cryptococcal meningitis, especially in sub-Saharan Africa. Its extensive use has …

Multi-azole-resistant strains of Cryptococcus neoformans var. grubii isolated from a FLZ-resistant strain by culturing in medium containing voriconazole

R Kano, M Okubo, A Hasegawa, H Kamata - Medical Mycology, 2017 - academic.oup.com
A Cryptococcus neoformans var. grubii strain, NUBS14020, was the first fluconazole (FLZ)-
resistant strain isolated from a feline cryptococcosis. Subsequent work demonstrated that …