Importance For patients with large vessel occlusion strokes, it is unknown whether
endovascular treatment alone compared with intravenous thrombolysis plus endovascular …

Importance Whether intravenous thrombolysis is needed in combination with mechanical
thrombectomy in patients with acute large vessel occlusion stroke is unclear. Objective To …

Background In acute ischemic stroke, there is uncertainty regarding the benefit and risk of
administering intravenous alteplase before endovascular thrombectomy. Methods We …

Importance It is estimated that only 27% of patients with acute ischemic stroke and large
vessel occlusion who undergo successful reperfusion after mechanical thrombectomy are …

Background and Purpose—We report the relation of onset-to-treatment time and door-to-
needle time with functional outcomes and mortality among patients with ischemic stroke with …

Background Among patients who had an ischaemic stroke presenting directly to a stroke
centre where endovascular thrombectomy (EVT) is immediately available, there is …

Importance Intravenous thrombolysis (IVT) followed by mechanical thrombectomy (MT) is
recommended to treat acute ischemic stroke (AIS) with a large vessel occlusion (LVO). Most …

Background Whether thrombectomy alone is equally as effective as intravenous alteplase
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …

Importance The effectiveness and safety of intravenous alteplase given before or
concurrently with endovascular thrombectomy (EVT) is uncertain. Randomized clinical trials …

Background Among patients with a proximal vessel occlusion in the anterior circulation, 60
to 80% of patients die within 90 days after stroke onset or do not regain functional …