The opioid receptor antagonist naltrexone is successfully used in the treatment of opioid and
alcohol dependence. However, questions have been raised about possible anhedonic side …

Background: The suppressive effect of opioid antagonists, such as naltrexone, on ethanol
intake has been suggested to be based on the interference with ethanol‐induced stimulation …

Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain
reward system and therefore blocks the rewarding effects of heroin and alcohol. It is …

Rats were implanted for 10 days with a slow-release pellet of naltrexone or were given sham
surgery. At one of various different intervals during or after implantation of the pellet, the …

There is evidence that naltrexone, an opioid antagonist, affects alcohol and food
consumption. Though food intake is inherently involved when naltrexone effects on alcohol …

Reports have shown that interspecies differences in the metabolism and pharmacokinetics
of naltrexone are a rule rather than exception. However, there is paucity of information on …

The opioid antagonist naltrexone has been shown to attenuate the subjective effects of
amphetamine. However, the mechanisms behind this modulatory effect are currently …

Background: Relapse after abstinence can be modelled in rats using an alcohol deprivation
effect (ADE) of enhanced ethanol consumption after a period of enforced abstinence from …

Aims: The opioid antagonist naltrexone may reduce ethanol reward, but the underlying
neurochemical mechanisms has yet to be clarified. The afferent projections to the nucleus …

Rats of the high-drinking AA line were given 1 mg/kg naltrexone (NTX) or vehicle orally with
a stress-free procedure just before 1 h of access to 10% ethanol daily for 8 days and again …