Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …

Iron is one of the most important elements for life, but excess iron is toxic. Intracellularly,
mitochondria are the center of iron utilization requiring sufficient amounts to maintain normal …

Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent.
Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate …

The mitochondrion plays vital roles in various aspects of cellular metabolism, ranging from
energy transduction and apoptosis to the synthesis of important molecules such as heme …

BACKGROUND: Iron is an essential element for life, as it is a cofactor for enzymes involved
in many metabolic processes, but it can also be harmful, since its excess is thought to …

It is well known that iron (Fe) is transported to the mitochondrion for heme synthesis.
However, only recently has the importance of this organelle for many other facets of Fe …

Mitochondria are an iconic distinguishing feature of eukaryotic cells. Mitochondria
encompass an active organellar network that fuses, divides, and directs a myriad of vital …

Mitochondria are involved in hematopoietic cell homeostasis through multiple ways such as
oxidative phosphorylation, various metabolic processes and the release of cytochrome c in …

Pathological overload of iron in the mitochondrial matrix has been observed in numerous
diseases, including sideroblastic anemias, which have many causes, and in genetic …

Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …