[HTML][HTML] Polyphenol-rich extract induces apoptosis with immunogenic markers in melanoma cells through the ER stress-associated kinase PERK
Polyphenols elicit antitumor activities, in part, through the induction of anti-or pro-oxidant
effects in cancer cells which promote priming of protective anti-tumor immunity. We recently …
effects in cancer cells which promote priming of protective anti-tumor immunity. We recently …
[HTML][HTML] The delay in cell death caused by the induction of autophagy by P2Et extract is essential for the generation of immunogenic signals in melanoma cells
P2Et extract obtained from the Caesalpinia spinosa plant is abundant in phenolic
compounds such as gallic acid and ethyl gallate and can generate signals to activate the …
compounds such as gallic acid and ethyl gallate and can generate signals to activate the …
[HTML][HTML] Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress
Endoplasmic reticulum (ER) stress triggers apoptosis by activating Bim in diverse types of
cells, which involves dephosphorylation of Bim EL by protein phosphatase 2A (PP2A) …
cells, which involves dephosphorylation of Bim EL by protein phosphatase 2A (PP2A) …
[HTML][HTML] Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity
J Wang, C Zhu, D Song, R Xia, W Yu, Y Dang… - Cell death …, 2017 - nature.com
Abstract Poly (ADP-ribose) polymerases (PARPs) are ADP-ribosylating enzymes and play
important roles in a variety of cellular processes. Most small-molecule PARP inhibitors …
important roles in a variety of cellular processes. Most small-molecule PARP inhibitors …
[HTML][HTML] Prophylactic vs. therapeutic treatment with P2Et polyphenol-rich extract has opposite effects on tumor growth
Polyphenols have tumoricidal effects via anti-proliferative, anti-angiogenic and cytotoxic
mechanisms and have recently been demonstrated to modulate the immune response …
mechanisms and have recently been demonstrated to modulate the immune response …
[HTML][HTML] PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells
N Sheshadri, DK Poria, S Sharan, Y Hu, C Yan… - Cell death & …, 2021 - nature.com
Cancer cells experience endoplasmic reticulum (ER) stress due to activated oncogenes and
conditions of nutrient deprivation and hypoxia. The ensuing unfolded protein response …
conditions of nutrient deprivation and hypoxia. The ensuing unfolded protein response …
Pinus radiata bark extract induces caspase-independent apoptosis-like cell death in MCF-7 human breast cancer cells
T Venkatesan, YW Choi, SP Mun, YK Kim - Cell biology and toxicology, 2016 - Springer
In the present study, we investigated the anticancer activity of Pinus radiata bark extract
(PRE) against MCF-7 human breast cancer cells. First, we observed that PRE induces …
(PRE) against MCF-7 human breast cancer cells. First, we observed that PRE induces …
Piperine promotes ultraviolet (UV)-B-induced cell death in B16F10 mouse melanoma cells through modulation of major regulators of cell survival
An increase in the incidence of melanoma and its resistance to currently applied treatment
regimes enhance the need for novel therapeutic agents and treatment modalities. In this …
regimes enhance the need for novel therapeutic agents and treatment modalities. In this …
Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis
H Zhao, L Han, Y Jian, Y Ma, W Yan… - OncoTargets and …, 2018 - Taylor & Francis
Background Resveratrol is known as a natural phytoalexin found in grapes and wine, which
has significant antitumor activity under in vitro and in vivo conditions. In recent years, great …
has significant antitumor activity under in vitro and in vivo conditions. In recent years, great …
[HTML][HTML] Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin
J Bakhshi, L Weinstein, KS Poksay, B Nishinaga… - Apoptosis, 2008 - Springer
The microenvironment of cancerous cells includes endoplasmic reticulum (ER) stress the
resistance to which is required for the survival and growth of tumors. Acute ER stress triggers …
resistance to which is required for the survival and growth of tumors. Acute ER stress triggers …