The primary objective of preclinical pain research is to improve the treatment of pain.
Decades of research using pain-evoked tests has revealed much about mechanisms but …

Rodents are commonly used to study the pathophysiological mechanisms of pain as studies
in humans may be difficult to perform and ethically limited. As pain cannot be directly …

Ensuring that laboratory rodent pain is well managed underpins the ethical acceptability of
working with these animals in research. Appropriate treatment of pain in laboratory rodents …

The measurement of spontaneous ongoing pain in rodents is a multiplex issue and a subject
of extensive and longstanding debate. Considering the need to align available rodent …

Despite the myriad promising new targets and candidate analgesics recently identified in
preclinical pain studies, little translation to novel pain medications has been generated. The …

Pain is ultimately a perceptual phenomenon. It is built from information gathered by
specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and …

Nociception and pain is a large field of both neuroscience and medical research. Over time,
various tests and models were developed in rodents to provide tools for fundamental and …

The use of effective regimens for mitigating pain remain underutilized in research rodents
despite the general acceptance of both the ethical imperative and regulatory requirements …

Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Pain measures traditionally used in rodents record mere reflexes evoked by sensory stimuli;
the results thus may not fully reflect the human pain phenotype. Alterations in physical and …