A complete telomere-to-telomere (T2T) finished genome has been the long pursuit of
genomic research. Through generating deep coverage ultralong Oxford Nanopore …

Creating gapless telomere-to-telomere assemblies of complex genomes is one of the
ultimate challenges in genomics. We use two independent assemblies and an optical map …

The first gapless, telomere‐to‐telomere (T2T) sequence assemblies of plant chromosomes
were reported recently. However, sequence assemblies of most plant genomes remain …

Motivation The advent of long-read DNA sequencing is allowing complete assembly of
highly repetitive genomic regions for the first time, including the megabase-scale satellite …

INTRODUCTION The centromeres of eukaryotic chromosomes assemble the multiprotein
kinetochore complex and thereby position attachment to the spindle microtubules, allowing …

The genomes of higher plants and animals are highly differentiated, and are composed of a
relatively small number of genes and a large fraction of repetitive DNA. The bulk of this …

Abstract The Telomere-to-Telomere consortium recently assembled the first truly complete
sequence of a human genome. To resolve the most complex repeats, this project relied on …

A high-quality genome is the basis for studies on functional, evolutionary, and comparative
genomics. The majority of attention has been paid to the solution of complex chromosome …

Complete and accurate reference genomes and annotations provide fundamental tools for
characterization of genetic and functional variation. These resources facilitate the …

The human genome reference sequence remains incomplete owing to the challenge of
assembling long tracts of near-identical tandem repeats in centromeres. We implemented a …