[HTML][HTML] Physiological implications of myocardial scar structure
WJ Richardson, SA Clarke, TA Quinn… - Comprehensive …, 2015 - ncbi.nlm.nih.gov
Once myocardium dies during a heart attack, it is replaced by scar tissue over the course of
several weeks. The size, location, composition, structure and mechanical properties of the …
several weeks. The size, location, composition, structure and mechanical properties of the …
Modifying the mechanics of healing infarcts: Is better the enemy of good?
SA Clarke, WJ Richardson, JW Holmes - Journal of molecular and cellular …, 2016 - Elsevier
Myocardial infarction (MI) is a major source of morbidity and mortality worldwide, with over 7
million people suffering infarctions each year. Heart muscle damaged during MI is replaced …
million people suffering infarctions each year. Heart muscle damaged during MI is replaced …
Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat
GM Fomovsky, JW Holmes - American Journal of …, 2010 - journals.physiology.org
The mechanical properties of the healing scar are an important determinant of heart function
following myocardial infarction. Yet the relationship between scar structure, scar mechanics …
following myocardial infarction. Yet the relationship between scar structure, scar mechanics …
Functional implications of myocardial scar structure
JW Holmes, JA Nuñez… - American Journal of …, 1997 - journals.physiology.org
During healing after myocardial infarction, scar collagen content and stiffness do not
correlate. We studied regional mechanics and both area fraction and orientation of large …
correlate. We studied regional mechanics and both area fraction and orientation of large …
Infarct scar as living tissue
Y Sun, MF Kiani, AE Postlethwaite… - Basic research in …, 2002 - Springer
Infarct scar tissue has long been considered inert (acellular, composed simply of fibrillar
collagen) and whose function is simply to restore structural integrity to infarcted myocardium …
collagen) and whose function is simply to restore structural integrity to infarcted myocardium …
The living scar–cardiac fibroblasts and the injured heart
Cardiac scars, often dubbed 'dead tissue', are very much alive, with heterocellular activity
contributing to the maintenance of structural and mechanical integrity following heart injury …
contributing to the maintenance of structural and mechanical integrity following heart injury …
Infarct scar: a dynamic tissue
Y Sun, KT Weber - Cardiovascular research, 2000 - academic.oup.com
Infarct scar, a requisite to the rebuilding of necrotic myocardium following myocardial
infarction (MI), has long been considered inert. Earlier morphologic studies suggested …
infarction (MI), has long been considered inert. Earlier morphologic studies suggested …
Mechanical regulation of fibroblast migration and collagen remodelling in healing myocardial infarcts
AD Rouillard, JW Holmes - The Journal of physiology, 2012 - Wiley Online Library
Key points• After myocardial infarction, fibroblasts infiltrate the necrotic myocardium, deposit
collagen, and remodel collagen, forming scar tissue.• Mechanical, structural, and chemical …
collagen, and remodel collagen, forming scar tissue.• Mechanical, structural, and chemical …
Electroanatomic characterization of post-infarct scars: comparison with 3-dimensional myocardial scar reconstruction based on magnetic resonance imaging
Objectives: This study was designed to compare electroanatomic mapping (EAM) and
magnetic resonance imaging (MRI) with delayed contrast enhancement (DCE) data for …
magnetic resonance imaging (MRI) with delayed contrast enhancement (DCE) data for …
Myocardial infarction remodeling that progresses to heart failure: a signaling misunderstanding
AJ Mouton, OJ Rivera… - American Journal of …, 2018 - journals.physiology.org
After myocardial infarction, remodeling of the left ventricle involves a wound-healing
orchestra involving a variety of cell types. In order for wound healing to be optimal …
orchestra involving a variety of cell types. In order for wound healing to be optimal …