Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the
patients′ capacity for daily functioning. Whereas our understanding of its pathophysiology …

Synchronization of neuronal activity in the neocortex may underlie the coordination of neural
representations and thus is critical for optimal cognitive function. Because cognitive deficits …

The hypothesis that alterations of cortical inhibitory γ-aminobutyric acid (GABA) neurons are
a central element in the pathology of schizophrenia has emerged from a series of …

Schizophrenia is a devastating illness that is manifest through a variety of clinical signs and
symptoms. Among these, impairments in certain critical cognitive functions, such as working …

Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …

The major cause of disability in schizophrenia is cognitive impairment, which remains
largely refractory to existing treatments. This reflects the fact that antipsychotics and other …

Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available
medications. Thus, understanding the neural basis of these deficits is crucial for the …

GABAergic interneurons control neuronal excitability, integration, and plasticity. Further, they
regulate the generation of temporal synchrony and oscillatory behavior among networks of …

Despite strenuous studies since the last century, the precise cause and pathology of
schizophrenia are still largely unclear and arguably controversial. Although many …

Abnormalities of GABAergic interneurons are some of the most consistent findings from post-
mortem studies of schizophrenia. However, linking these molecular deficits with in vivo …