Although much maligned, the amyloid-β (Aβ) protein has been shown to possess a number
of trophic properties that emanate from the protein's ability to bind Cu, Fe and Zn. Aβ …

Elevated production of amyloid-β (Aβ) as a preventive antioxidant for brain lipoproteins
under the action of increased oxidative stress in aging is postulated to represent a major …

Recent data from several groups suggest that the primary mechanism of β‐amyloid
neurotoxicity may be mediated by reactive oxygen species. To evaluate this hypothesis, we …

Amyloid-β protein (Aβ) aggregates in the brain to form senile plaques. By using thioflavin T,
a dye that specifically binds to fibrillar structures, we found that metals such as Zn (II) and Cu …

Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

Redox chemistry arising from transition metals copper and iron are the principal chemical
origin of the radicals and reactive oxygen species that are implicated in the pathogenesis of …

Considerable evidence is mounting that dyshomeostasis of the redox‐active biometals, Cu
and Fe, and oxidative stress contribute to the neuropathology of Alzheimer's disease (AD) …

Alzheimer's disease is characterized by signs of a major oxidative stress in the neocortex
and the concomitant deposition of Amyloid beta (Aβ). Aβ is a metalloprotein that binds …

Amyloid beta (Aβ) is a peptide of 39–43 amino acids found in large amounts and forming
deposits in the brain tissue of patients with Alzheimer's disease (AD). For this reason, it has …

Metal ions, including copper and zinc, have been implicated in the pathogenesis of
Alzheimer's disease through a variety of mechanisms including increased amyloid-β affinity …