Ca2+ is a key secondary messenger that determines sperm motility patterns. Mammalian
sperm undergo capacitation, a process to acquire fertilizing ability, in the female …

Ca2+ is a key secondary messenger that modulates sperm motility by tuning flagellar
movement in various species. The sperm-specific Ca2+ channel, CatSper, is a primary Ca2+ …

The molecular mechanisms underlying Ca2+ entry into sperm are now much more well
defined thanks to direct recordings of mature sperm cells. This article reviews the function of …

Background: Ca 2+ signals, elicited by cues from the oocyte and female tract, regulate
human sperm behavior. Results: CatSper channel activation (flagellum) and Ca 2+ store …

The flagellar-specific Ca2+ channel CatSper is the predominant Ca2+ entry site in
mammalian sperm. CatSper-mediated Ca2+ signaling affects nearly every event that …

Highlights•In vivo, a successful fertilization is dependent on sperm hyperactivated motility.•
Hyperactivation is triggered by a calcium influx into flagellum via sperm-specific calcium …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Mammalian sperm must undergo capacitation as a preparation for entering into
hyperactivated motility, undergoing the acrosome reaction, and acquiring fertilizing ability …

Elevation of intracellular Ca2+ regulate sperm motility, chemotaxis, capacitation and the
acrosome reaction, and play a vital role in the ability of the sperm cell to reach and fertilize …

Abstract Calcium ions (Ca 2+) are involved in nearly every aspect of cellular life. They are
one of the most abundant elements in mammals and play a vital role in physiological and …