Maintenance of plasma membrane integrity is essential for normal cell viability and function.
Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of …

Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

Plasma membrane forms the barrier between the cytoplasm and the environment. Cells
constantly and selectively transport molecules across their plasma membrane without …

Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience
plasma membrane damage from a multitude of stressors in the extra-and intra-cellular …

Plasma membrane repair is a conserved cellular response mediating active resealing of
membrane disruptions to maintain homeostasis and prevent cell death and progression of …

Highlights•Clogging of wounds can occur by vesicle patching or proteins
aggregation.•Removal of small wounds can occur by endocytosis or shedding.•Exocytosis …

Resealing allows cells to mend damaged membranes rapidly when plasma membrane (PM)
disruptions occur. Models of PM repair mechanisms include the “lipid-patch”,“endocytic …

Since an intact membrane is required for normal cellular homeostasis, membrane repair is
essential for cell survival. Human genetic studies, combined with the development of novel …

▪ Abstract Many metazoan cells inhabit mechanically stressful environments and,
consequently, their plasma membranes are frequently disrupted. Survival requires that the …

The plasma membrane defines the boundary of every living cell, and its integrity is essential
for life. The plasma membrane may, however, be challenged by mechanical stress or pore …