Novel concepts and understanding of receptors lead to discoveries and optimization of
many small molecules and antibodies as anti-cancerous drugs. Receptor tyrosine kinases …

Tyrosine kinases (TKs) are key mediators of signalling pathways in cells. Located at the
surface of the cell, within the cytoplasm or in the nucleous, TKs have been showed to be …

Conventional cytotoxic chemotherapy involving DNA-interacting agents and indiscriminate
cell death is no longer the future of cancer management. While chemotherapy is not likely to …

Receptor tyrosine kinases play a significant role in carcinogenesis and have been
successfully targeted with monoclonal antibodies and small-molecule inhibitors. There have …

Receptor tyrosine kinases (RTKs) are cell surface transmembrane proteins responsible for
intracellular signal transduction. They are expressed in several cell types and, after …

Receptor and non-receptor protein tyrosine kinases (PTKs) are essential enzymes in cellular
signaling processes and signal transduction pathways that regulate cell growth …

Molecular communication, which involves sending, receiving and promoting signals, is
essential for cell growth and division. A group of cell surface molecules called" receptor …

Receptor tyrosine kinases (RTKs) are transmembrane proteins that play a critical role in
stimulating signal transduction cascades to influence cell proliferation, growth, and …

Anti-cancer targeting drugs appear to be a new and powerful" weapon" for cancer therapies.
These targeting drugs are directed against specific molecules that are over-expressed or …

Abstract In 1989-91, George Zhu first postulate oncogenic receptor, as a result of his
experiments in which steroid PML-RARa fusion receptor gene rearrangement within t (15; …