Pipolins are bimodular platforms that maintain a reservoir of defense systems exchangeable with various bacterial genetic mobile elements

V Mateo Caceres, M Redrejo Rodriguez - bioRxiv, 2024 - biorxiv.org
Defense genes gather in diverse types of genomic islands in bacteria and provide immunity
against viruses and other genetic mobile elements. Here, we disclose pipolins, previously …

ExplorePipolin: reconstruction and annotation of bacterial mobile elements from draft genomes

L Chuprikova, V Mateo-Cáceres, M de Toro… - bioRxiv, 2022 - biorxiv.org
Motivation Detailed and accurate analysis of mobile genetic elements (MGEs) in bacteria is
essential to deal with the current threat of multiresistant microbes. The overwhelming use of …

ExplorePipolin: reconstruction and annotation of piPolB-encoding bacterial mobile elements from draft genomes

L Chuprikova, V Mateo-Cáceres… - Bioinformatics …, 2022 - academic.oup.com
Motivation Detailed and accurate analysis of mobile genetic elements (MGEs) in bacteria is
essential to deal with the current threat of multiresistant microbes. The overwhelming use of …

[HTML][HTML] High diversity and variability of pipolins among a wide range of pathogenic Escherichia coli strains

SC Flament-Simon, M de Toro, L Chuprikova… - Scientific Reports, 2020 - nature.com
Self-synthesizing transposons are integrative mobile genetic elements (MGEs) that encode
their own B-family DNA polymerase (PolB). Discovered a few years ago, they are proposed …

[PDF][PDF] 2 High diversity and variability of pipolins among a wide range of 3 pathogenic Escherichia coli strains

JMG Blanco, M Salas, J Blanco, M Redrejo-Rodríguez - academia.edu
63 Mobile genetic elements (MGE), comprising bacteriophages, transposons, plasmids, 64
and insertion sequences, contribute to the great plasticity of the bacterial genome, 65 …

Mobile Integrons Encode Phage Defence Systems

N Kieffer, A Hipolito, P Blanco, T Delobelle, FM Ojeda… - bioRxiv, 2024 - biorxiv.org
Integrons are bacterial genetic elements that capture, stockpile and modulate the expression
of genes encoded in integron cassettes. Mobile Integrons (MI) are borne on plasmids, acting …

[HTML][HTML] Microbial genomics: the expanding universe of bacterial defense systems

KJ Forsberg, HS Malik - Current Biology, 2018 - cell.com
Bacteria protect themselves against infection using multiple defensive systems that move by
horizontal gene transfer and accumulate in genomic 'defense islands'. A recent study …

[HTML][HTML] Functional enrichment of integrons: Facilitators of antimicrobial resistance and niche adaptation

TM Ghaly, V Rajabal, A Penesyan, NV Coleman… - Iscience, 2023 - cell.com
Integrons are genetic elements, found among diverse bacteria and archaea, that capture
and rearrange gene cassettes to rapidly generate genetic diversity and drive adaptation …

Going viral: The role of mobile genetic elements in bacterial immunity

B Beamud, F Benz, D Bikard - Cell Host & Microbe, 2024 - cell.com
Bacteriophages and other mobile genetic elements (MGEs) pose a significant threat to
bacteria, subjecting them to constant attacks. In response, bacteria have evolved a …

ExplorePipolin: a pipeline for identification and exploration of pipolins, novel mobile genetic elements widespread among bacteria

L Chuprikova - 2020 - repositorio.uam.es
Pipolins constitute a new group of self-synthesizing or self-replicating mobile genetic
elements (MGEs), encoding for their own replicative DNA polymerase B. These elements …