What makes a P450 tick?
The cytochromes P450 (P450s) are probably nature's most versatile enzymes in terms of
both their vast substrate range and the diverse types of molecular transformations performed …
both their vast substrate range and the diverse types of molecular transformations performed …
[HTML][HTML] Reactive intermediates in cytochrome P450 catalysis
CM Krest, EL Onderko, TH Yosca, JC Calixto… - Journal of Biological …, 2013 - ASBMB
Recently, we reported the spectroscopic and kinetic characterizations of cytochrome P450
compound I in CYP119A1, effectively closing the catalytic cycle of cytochrome P450 …
compound I in CYP119A1, effectively closing the catalytic cycle of cytochrome P450 …
Cytochromes P450 (P450s): A review of the class system with a focus on prokaryotic P450s
JD Finnigan, C Young, DJ Cook, SJ Charnock… - Advances in protein …, 2020 - Elsevier
Abstract Cytochromes P450 (P450s) are a large superfamily of heme-containing
monooxygenases. P450s are found in all Kingdoms of life and exhibit incredible diversity …
monooxygenases. P450s are found in all Kingdoms of life and exhibit incredible diversity …
Cytochrome P450: Significance, reaction mechanisms and active site analogues
WD Woggon - Bioorganic Chemistry: Models and Applications, 2005 - Springer
The significance of cytochrome P450 catalyzed reactions has now been recognized for more
than 30 years [1] as one of nature's most common and sophisticated methods to oxidize …
than 30 years [1] as one of nature's most common and sophisticated methods to oxidize …
Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs
FP Guengerich, NA Hosea, A Parikh… - Drug Metabolism and …, 1998 - ASPET
Today cytochrome P450 (P450) research is accepted as an integral part of drug
development and discovery. Work leading to this point included biochemical studies on …
development and discovery. Work leading to this point included biochemical studies on …
Uncommon P450-catalyzed reactions
F Guengerich - Current drug metabolism, 2001 - ingentaconnect.com
Cytochrome P450 (P450) enzymes play major roles in the metabolism of drugs,
carcinogens, steroids, eicosanoids, alkaloids, pesticides, and other important xenobiotics, as …
carcinogens, steroids, eicosanoids, alkaloids, pesticides, and other important xenobiotics, as …
Cytochrome P450 monooxygenases
LL Wong - Current opinion in chemical biology, 1998 - Elsevier
The field of P450 research is progressing rapidly. The active sites of structurally
characterized bacterial P450 enzymes have been rationally re-engineered to alter both …
characterized bacterial P450 enzymes have been rationally re-engineered to alter both …
A passion for P450s (remembrances of the early history of research on cytochrome P450)
RW Estabrook - Drug metabolism and disposition, 2003 - ASPET
Many members of the superfamily of hemeproteins, known as cytochrome P450 (P450 or
CYP), are currently described in the literature (over 2000 at the date of this writing)[see …
CYP), are currently described in the literature (over 2000 at the date of this writing)[see …
Recent structural insights into cytochrome P450 function
FP Guengerich, MR Waterman, M Egli - Trends in pharmacological …, 2016 - cell.com
Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …
Complex reactions catalyzed by cytochrome P450 enzymes
EM Isin, FP Guengerich - Biochimica et Biophysica Acta (BBA)-General …, 2007 - Elsevier
Cytochrome P450 (P450) enzymes are some of the most versatile redox proteins known.
The basic P450 reactions include C-hydroxylation, heteroatom oxygenation, heteroatom …
The basic P450 reactions include C-hydroxylation, heteroatom oxygenation, heteroatom …