The key regulators of the transcriptional response to hypoxia and inflammation (hypoxia
inducible factor, HIF, and nuclear factor-kappa B, NF-κB, respectively) are evolutionarily …

Hypoxia and inflammation are frequently co-incidental features of the tissue
microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on …

Hypoxia is a feature of the microenvironment in a number of chronic inflammatory conditions
due to increased metabolic activity and disrupted perfusion at the inflamed site. Hypoxia …

Uncontrolled inflammation underpins a diverse range of diseases where effective therapy
remains an unmet clinical need. Hypoxia is a prominent feature of the inflammatory …

The oxygen-sensitive transcription factor hypoxia inducible factor (HIF) is a key regulator of
gene expression during adaptation to hypoxia. Crucially, inflamed tissue often displays …

Decreased oxygen availability (hypoxia) is a hallmark feature of the microenvironment in a
number of chronic inflammatory conditions including arthritis and inflammatory bowel …

Sites of inflammation are defined by significant changes in metabolic activity. Recent studies
have suggested that O2 metabolism and hypoxia play a prominent role in inflammation so …

Uncontrolled or non-resolving inflammation underpins a range of disease states including
rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Hypoxia is a …

Hypoxia-inducible factor (HIF) is an important transcriptional regulator of cell metabolism
and the adaptation to cellular stress caused by oxygen deficiency (hypoxia). Phagocytic …

Hypoxia and inflammation have been associated with a number of pathological conditions,
in particular inflammatory diseases. While hypoxia is mainly associated with the activation of …