Double-stranded DNA (dsDNA) in the cytoplasm of eukaryotic cells is abnormal and typically
indicates the presence of pathogens or mislocalized self-DNA. Multiple sensors detect …

Immunotherapy is a fundamental pillar in the treatment of lung cancer but remains inefficient
in half of the treated patients. Recent clinical trials showed synergistic effects of combining …

Activating stimulator of interferon genes to turn immunologically refractive cold tumor hot is
an exciting therapeutic approach to increase the clinical responsiveness of some human …

Spontaneous T cell responses against tumors occur frequently and have prognostic value in
patients. The mechanism of innate immune sensing of immunogenic tumors leading to …

Abstract The Stimulator of Interferon Genes (STING) is activated by cytosolic DNA sensors
such as cyclic GMP-AMP Synthase (cGAS) to induce interferon type I (IFN-I). Dendritic cells …

Abstract The Stimulator of Interferon Genes (STING) is a signaling adaptor associated with
the endoplasmic reticulum. STING is activated by cytosolic DNA sensors to stimulate IFN …

Ovarian cancer is the sixth most prevalent cancer in women and the most lethal of the
gynecologic malignancies. Our group has recently shown that STING signaling is often …

Stimulator of interferon genes (STING) is a cellular sensor that controls cytosolic DNA-
activated innate immune signaling. We have previously demonstrated that STING-deficient …

We have previously identified a DNA damage response deficient (DDRD) subgroup in
breast cancer, associated with loss of the Fanconi Anemia/BRCA DNA repair pathway. The …

The production of cytokines in response to DNA-damage events may be an important host
defense response to help prevent the escape of pre-cancerous cells. The innate immune …