Myelocytomatosis‐protein arginine N‐Methyltransferase 5 Axis defines the tumorigenesis and immune response in hepatocellular carcinoma

Y Luo, Y Gao, W Liu, Y Yang, J Jiang, Y Wang… - …, 2021 - Wiley Online Library
Background and Aims HCC is a leading cause of cancer‐related deaths globally with poor
outcome and limited therapeutic options. Although the myelocytomatosis (MYC) oncogene is …

Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A

Y Lei, P Han, Y Chen, H Wang, S Wang… - Clinical and …, 2022 - Wiley Online Library
Background Protein arginine methylation has emerged a pivotal role in cancer progression.
However, the role of protein arginine methyltransferase 3 (PRMT3) in hepatocellular …

The polymorphism rs975484 in the protein arginine methyltransferase 1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma

M Schonfeld, J Zhao, A Komatz, SA Weinman… - Journal of Biological …, 2020 - ASBMB
Protein arginine methyltransferase 1 (PRMT1) is a key regulator of hepatic immune
responses. Recently, we reported that PRMT1 regulates the tumor immune response in …

[HTML][HTML] Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC

JW Ryu, SK Kim, MY Son, SJ Jeon, JH Oh, JH Lim… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a major type of liver cancer caused by the hepatitis B
and C viruses, alcohol and exposure to aflatoxin. For HCC treatment, anticancer drugs have …

PRMT 9 promotes hepatocellular carcinoma invasion and metastasis via activating PI 3K/Akt/GSK‐3β/Snail signaling

H Jiang, Z Zhou, S Jin, K Xu, H Zhang, J Xu… - Cancer …, 2018 - Wiley Online Library
Protein arginine methyltransferases (PRMT) catalyze protein arginine methylation and play
an important role in many biological processes. Aberrant PRMT expression in tumor cells …

The protein arginine methyltransferase 5 promotes malignant phenotype of hepatocellular carcinoma cells and is associated with adverse patient outcomes after …

D Shimizu, M Kanda, H Sugimoto… - International …, 2017 - spandidos-publications.com
The prognosis of advanced hepatocellular carcinoma (HCC) is dismal. Novel molecular
targets for diagnosis and therapy is urgently required. This study evaluated expression and …

Targeting protein arginine methyltransferase 5 inhibits human hepatocellular carcinoma growth via the downregulation of beta-catenin

B Zhang, S Dong, Z Li, L Lu, S Zhang, X Chen… - Journal of translational …, 2015 - Springer
Background Protein arginine methyltransferase 5 (PRMT5), a type II PRMT, is highly
expressed in some tumors, but its role in hepatocellular carcinoma (HCC) is still unknown …

Inhibiting type I arginine methyltransferase activity promotes T cell–mediated antitumor immune responses

A Fedoriw, L Shi, S O'Brien, KN Smitheman… - Cancer immunology …, 2022 - AACR
Protein arginine methyltransferases (PRMT) are a widely expressed class of enzymes
responsible for catalyzing arginine methylation on numerous protein substrates. Among …

The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma

Z Li, J Zhang, X Liu, S Li, Q Wang, D Chen, Z Hu… - Nature …, 2018 - nature.com
Recurrent chromosomal aberrations have led to the discovery of oncogenes or tumour
suppressors involved in carcinogenesis. Here we characterized an oncogenic long …

PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation

G Hu, C Yan, P Xie, Y Cao, J Shao, J Ge - Experimental Cell Research, 2020 - Elsevier
Protein arginine methyltransferases (PRMTs) have been implicated in the development of
various cancers. PRMT2, a member of the type I PRMT family, is overexpressed in multiple …