Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …

The nature of obesity-associated islet inflammation and its impact on β cell abnormalities
remains poorly defined. Here, we explore immune cell components of islet inflammation and …

Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion
from pancreatic β‐cells. Inflammatory cytokines, including tumour necrosis factor‐α (TNF‐α) …

Obesity is a major public health problem worldwide, and it is associated with an increased
risk of developing type 2 diabetes. It is now commonly accepted that chronic inflammation …

Inflammation plays an important role in the destruction of pancreatic islet β-cells that leads to
type I diabetes. This involves infiltration of T-cells and macrophages into the islets and local …

Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …

Activation of the innate immune system in obesity is a risk factor for the development of type
2 diabetes. The aim of the current study was to investigate the notion that increased …

It has been demonstrated in rodents and humans that chronic inflammation characterized by
macrophage infiltration occurs mainly in adipose tissue or liver during obesity, in which …

The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …

It has been increasingly accepted that chronic subacute inflammation plays an important
role in the development of insulin resistance and type 2 Diabetes in animals and humans …