TGF-ß has a biphasic role in tumorigenesis. In earlyphases, when cells still respond to the
growth inhibitory effects of TGFß, it may act as tumor suppressor. However, in late phases …

Exprese sTGFbetaRII-Fc-Jun z rekombinantního viru vakcinie TGFbeta má při karcinogenezi
dvojí roli. V počátku slouží jako nádorový supresor, během růstu nádoru se však jeho funkce …

Recent advances in understanding tumor biology have provided new opportunities to
develop effective approaches to treat patients with cancer. Intensive research on molecular …

Transforming growth factor β (TGF-β) superfamily ligands have important roles in regulating
cellular homeostasis, embryonic development, differentiation, proliferation, immune …

The TGF-β1 cytokine is a key mediator of many biological processes. Complex regulatory
mechanisms are in place that allow one single molecule to exert so many distinct …

Transforming growth factor (TGF)‐β is a multitasking cytokine such that its aberrant
expression is related to cancer progression and metastasis. TGF‐β is produced by a variety …

The physiological functions of transforming growth factor (TGF)-β in cell signaling include
regulation of developmental processes and cell growth. Tumor cells very often display …

Abstract 2076 Transforming growth factor beta (TGFβ) is a ubiquitous cytokine that regulates
many cellular processes throughout growth and development. In cancer, TGFβ has shown …

There is abundant evidence in cell and animal models that increased expression and/or
activation of TGF-β can act as an autocrine as well as a paracrine factor to promote tumor …

The transforming growth factor-β (TGF-β) signaling pathway plays dual roles in epithelial cell
tumorigenesis. TGF-β is initially growth inhibitory, but as tumorigenesis progresses, TGF-β …