Until the 1970s, reactive oxygen species (ROS) were considered merely harmful by-
products of aerobic respiration and the driving force behind the evolution of an array of …

Reactive oxygen species (ROS) are produced by all vascular cells and regulate the major
physiological functions of the vasculature. Production and removal of ROS are tightly …

The implications of reactive oxygen species in cardiovascular disease have been known for
some decades. Rationally, therapeutic antioxidant strategies combating oxidative stress …

Oxygen-derived free radicals are thought to contribute to the initiation and progression of
cardiovascular disease via several different mechanisms, such as consumption of nitric …

Increased oxidative stress plays an important role in the pathophysiology of cardiovascular
diseases such as hypertension, atherosclerosis, diabetes, cardiac hypertrophy, heart failure …

Reactive oxygen species (ROS) have been shown to play important functions as signaling
molecules in the vasculature. Several NADPH oxidase isoforms have been identified in …

Oxidative stress is a molecular dysregulation in reactive oxygen species (ROS) metabolism,
which plays a key role in the pathogenesis of atherosclerosis, vascular inflammation and …

Vascular cells have evolved to use reactive oxygen species (ROS), such as superoxide and
hydrogen peroxide, as signalling molecules. Under physiological conditions, ROS are …

Intracellular ROS (reactive oxygen species) such as superoxide and H2O2 have been
increasingly appreciated to have a role in endothelial pathophysiology. Of the several …

Endothelial dysfunction comprising impairment of endothelium-dependent vasodilator
function and increased endothelial activation contributes to the pathophysiology of …