Myocardial remodeling and dysfunction caused by accelerated oxidative damage is a widely
reported phenomenon within a diabetic state. Altered myocardial substrate preference …

The accumulation of oxidative damage to DNA and other biomolecules plays an important
role in the etiology of aging and age-related diseases such as type 2 diabetes mellitus …

Excessive β-adrenergic stimulation causes cardiac toxicity, which also contributes to cardiac
oxidative stress. Although uncoupling protein 2 (UCP2), a member of the mitochondrial inner …

Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction,
progressing eventually to the final end point heart failure (HF), remain the leading cause of …

Metabolic diseases such as obesity, metabolic syndrome, and type II diabetes are often
characterized by increased reactive oxygen species (ROS) generation in mitochondrial …

Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial anion carrier proteins. It
uncouples oxygen consumption from ATP synthesis. UCP2 is ubiquitously expressed in …

The risk for heart failure and death after myocardial infarction is abnormally high in diabetic
subjects. We and others have shown previously that mitochondrial uncoupling protein 3 …

Patients with insulin resistance and type 2 diabetes have poor cardiac outcomes following
myocardial infarction (MI). The mitochondrial uncoupling protein 3 (UCP3) is down …

Uncoupling proteins (UCPs) are located in the mitochondrial inner membrane and partially
dissipate the transmembrane proton electrochemical gradient. UCP2 is expressed in various …

Diabetic rats have a deficiency in their heart ATP concentrations, and although the
mechanism remains to be elucidated, this deficiency may involve increased uncoupling of …