Amyloid beta and phosphorylated tau-induced defective autophagy and mitophagy in Alzheimer's disease

PH Reddy, DMA Oliver - Cells, 2019 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. Several decades of intense research have …

Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse

H Morton, S Kshirsagar, E Orlov, LE Bunquin… - Free Radical Biology …, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. AD is marked by multiple cellular changes …

Defective autophagy and mitophagy in aging and Alzheimer's disease

M Tran, PH Reddy - Frontiers in neuroscience, 2021 - frontiersin.org
Aging is the time-dependent process that all living organisms go through characterized by
declining physiological function due to alterations in metabolic and molecular pathways …

Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease

V Bhatia, S Sharma - Journal of the neurological sciences, 2021 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia. The pathological hallmarks
of AD are amyloid plaques [aggregates of amyloid beta (A)] and neurofibrillary tangles …

Autophagic dysfunction in Alzheimer's disease: cellular and molecular mechanistic approaches to halt Alzheimer's pathogenesis

MS Uddin, AA Mamun, ZK Labu… - Journal of cellular …, 2019 - Wiley Online Library
Autophagy is a preserved cytoplasmic self‐degradation process and endorses recycling of
intracellular constituents into bioenergetics for the controlling of cellular homeostasis …

The ambiguous relationship of oxidative stress, tau hyperphosphorylation, and autophagy dysfunction in Alzheimer's disease

Z Liu, T Li, P Li, N Wei, Z Zhao, H Liang… - Oxidative medicine …, 2015 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia. The pathological hallmarks
of AD are amyloid plaques [aggregates of amyloid‐beta (Aβ)] and neurofibrillary tangles …

Mitochondrial dysfunction-the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity

A Eckert, K Schmitt, J Götz - Alzheimer's research & therapy, 2011 - Springer
The pathology of Alzheimer's disease (AD) is characterized by amyloid plaques (aggregates
of amyloid-β (Aβ)) and neurofibrillary tangles (aggregates of tau) and is accompanied by …

Exploring the bi‐directional relationship between autophagy and Alzheimer's disease

H Kuang, CY Tan, HZ Tian, LH Liu… - CNS neuroscience & …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is characterized by β‐amyloid (Aβ) deposition and Tau
phosphorylation, in which its pathogenesis has not been cleared so far. The metabolism of …

Alzheimer's disease pathogenesis: Role of autophagy and mitophagy focusing in microglia

M Eshraghi, A Adlimoghaddam… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial …

M Manczak, PH Reddy - Human molecular genetics, 2012 - academic.oup.com
We recently reported increased mitochondrial fission and decreased fusion, increased
amyloid beta (Aβ) interaction with the mitochondrial fission protein Drp1, increased …