The objective of this study was to systematically assess literature datasets and quantitatively
analyze metformin PK in plasma and some tissues of nine species. The pharmacokinetic …

Metformin is the primary drug for type 2 diabetes treatment and a promising candidate for
other disease treatment. It has significant deviations between individuals in therapy …

Abstract Background and Objective Metformin is contraindicated in patients with renal
impairment; however, there is poor adherence to current dosing guidelines. In addition, the …

Objective: To assess the average bioequivalence of two formulations of metformin after
single-dose administration of each treatment to healthy subjects under fasting conditions by …

The exposure‐response properties of metformin were characterized in 12 subjects with type
2 diabetes mellitus. The time course of drug concentration and effects on fasting plasma …

Metformin, a synthetic biguanide, is currently one of the most frequently recommended
medications for type 2 diabetes treatment around the world. This review presents the latest …

Purpose The objective of this study was to develop a population pharmacokinetic model and
investigate the effect of several demographic covariates on metformin pharmacokinetics in …

Background and objectives Physiologically based pharmacokinetic (PBPK) modelling and
simulation enable researchers to overcome practical limitations for clinical trials on special …

Metformin is commonly used as first‐line treatment for T2DM (type2 diabetes mellitus).
Owing to the high pharmacokinetic (PK) variability, several population pharmacokinetic …

The dependency of metformin in vivo disposition on the rate and extent of dissolution was
studied. The analysis includes the use of fundamental principles of drug input, permeability …