Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back

P Kharel, G Becker, V Tsvetkov… - Nucleic acids research, 2020 - academic.oup.com
Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …

Detecting RNA G-quadruplexes (rG4s) in the transcriptome

CK Kwok, G Marsico… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
SUMMARY RNA G-quadruplex (rG4) secondary structures are proposed to play key roles in
fundamental biological processes that include the modulation of transcriptional, co …

RNA G-quadruplexes (rG4s): genomics and biological functions

K Lyu, EYC Chow, X Mou, TF Chan… - Nucleic acids …, 2021 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

G-Quadruplexes in RNA biology: recent advances and future directions

L Dumas, P Herviou, E Dassi, A Cammas… - Trends in Biochemical …, 2021 - cell.com
RNA G-quadruplexes (RG4s) are four-stranded structures known to control gene expression
mechanisms, from transcription to protein synthesis, and DNA-related processes. Their …

QUADRatlas: the RNA G-quadruplex and RG4-binding proteins database

S Bourdon, P Herviou, L Dumas… - Nucleic Acids …, 2023 - academic.oup.com
Abstract RNA G-quadruplexes (RG4s) are non-canonical, disease-associated post-
transcriptional regulators of gene expression whose functions are driven by RNA-binding …

RNA G-quadruplexes in biology: principles and molecular mechanisms

MM Fay, SM Lyons, P Ivanov - Journal of molecular biology, 2017 - Elsevier
Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …

RNA G-quadruplex structures control ribosomal protein production

D Varshney, SM Cuesta, B Herdy, UB Abdullah… - Scientific Reports, 2021 - nature.com
Four-stranded G-quadruplex (G4) structures form from guanine-rich tracts, but the extent of
their formation in cellular RNA and details of their role in RNA biology remain poorly defined …

RNA G-quadruplexes: emerging mechanisms in disease

A Cammas, S Millevoi - Nucleic acids research, 2017 - academic.oup.com
Abstract RNA G-quadruplexes (G4s) are formed by G-rich RNA sequences in protein-coding
(mRNA) and non-coding (ncRNA) transcripts that fold into a four-stranded conformation …

Transcriptome-wide identification of transient RNA G-quadruplexes in human cells

SY Yang, P Lejault, S Chevrier, R Boidot… - Nature …, 2018 - nature.com
Guanine-rich RNA sequences can fold into four-stranded structures, termed G-quadruplexes
(G4-RNAs), whose biological roles are poorly understood, and in vivo existence is debated …

The regulation and functions of DNA and RNA G-quadruplexes

D Varshney, J Spiegel, K Zyner, D Tannahill… - … reviews Molecular cell …, 2020 - nature.com
DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …